Postdoctoral researcher 'Circadian control of vascular inflammat
Karolinska Institutet, / Biomedicinjobb / Stockholm
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At the Department of Physiology and Pharmacology (
http://ki. se/fyfa_english) we teach and conduct research in Physiology, Pharmacology, Anaesthesiology and Intensive care. We have around 400 employees, 30 research groups, and 90 doctoral students.
Background
The research at our Inflammation Physiology lab aims to understand the pathophysiological mechanisms of atherosclerosis, the underlying pathology for myocardial infarction and stroke and hence responsible for most deaths worldwide. We have identified the importance of neutrophils as key drivers of vascular inflammation, unveiled important processes these cells set off, and designed preclinical intervention strategies aimed at halting these processes (e.g. Silvestre-Roig, Nature, 2019; Paulin et al., Circulation, 2018; Alard et al., Sci Transl Med, 2015). In recent years we have learnt that acute cardiovascular events peak at a certain time of day and our studies have revealed circadian leukocyte recruitment as possible cause for such pattern (Winter et al., Cell Metab 2018). We have now teamed up with Novo Nordisk to map changes in circadian gene and protein expression in depth to develop innovative strategies of chronopharmacological intervention.
Duties
We are looking for a postdoctoral researcher who will employ advanced bioinformatics of transcriptomic and proteomic data sets to map changes across tissues over the day.
Entry requirements
Qualified for the position is one who has obtained a doctorate or has equivalent scientific competence.
Qualifications
The applicant should have a PhD degree with focus on bioinformatics and have an interest in physiology, inflammation, and circadian biology. Basic understanding in systems biology and analysis of large scale data sets are required. Coding skills (e.g. R, python), the ability to set up pipelines, and the ability to work independently are needed. Taking own initiative to move this project forward is desired. Basic understanding in simple wet lab techniques (e.g. RNA extraction) is a plus. Furthermore, good communication skills and good proficiency in spoken and written English are necessary.
Application process
An application must contain the following documents in English:
- Curriculum vitae and qualifications,
- A complete list of publications
- A summary of current work (no more than one page)
The application is to be submitted on the Varbi system.
Karolinska Institutet is one of the world 's leading medical universities. Its mission is to contribute to the improvement of human health through research and education. Karolinska Institutet accounts for over 40 per cent of the medical academic research conducted in Sweden and offers the country 's broadest range of education in medicine and health sciences. Since 1901 the Nobel Assembly at Karolinska Institutet has selected the Nobel laureates in Physiology or Medicine.
Pursuant to the regulations of the Swedish National Archives, applications are kept on file for two years after the appointment has gained legal force. The regulations do not apply to attachments that have been printed or otherwise published.
Karolinska Institutet strives to provide a workplace that has approximately the same number of women and men, is free of discrimination and offers equal opportunity to everyone.
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Varaktighet, arbetstid
100 %. Tillträde: By agreement Visstidsanställning
Publiceringsdatum2020-01-22ErsättningMonthly payment
Så ansöker duSista dag att ansöka är 2020-02-15
Klicka på denna länk för att göra din ansökanFöretagKarolinska Institutet,
Arbetsgivarens referens Arbetsgivarens referens för detta jobb är "2-303/2020".
Omfattning Detta är ett heltidsjobb.
Arbetsgivare Karolinska Inst (org.nr 202100-2973)
Arbetsplats Karolinska Institutet,
Jobbnummer 5055833
Observera att sista ansökningsdag har passerat.