Postdoctoral fellow in tumor immunology
Göteborgs universitet / Apotekarjobb / Göteborg
2013-02-11
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Postdoctoral fellow in tumor immunology
Type of employment: Fixed-term employment, 2 år
Extent: 100 %
Location: Institute of Biomedicine, Göteborg
First day of employment: As agreed
Reference number: PER 2013/35
The group focuses on the development of immunotherapies for myeloid leukemias in collaboration with several clinical hematology units. The group has initiated and conducted several phase II and phase III clinical trials in leukemia. For more information see:
http://www.cancercenter.gu.se/research/kristoffer-hellstrand/Subject area
tumor immunology
Specific subject description
Reactive oxygen species (ROS or ?oxygen radicals?) produced by the NADPH oxidase of myeloid cells are potent inhibitors of cellular immunity, triggering programmed cell death and dysfunction in NK cells and T cells. Inhibition of NADPH oxidase-dependent ROS formation restores lymphocyte function and lymphocyte responsiveness to cytokines. An NADPH oxidase inhibitor (HDC) was recently approved in acute myeloid leukemia (AML) for the prevention of relapse among patients who have achieved complete remission after chemotherapy (Blood 108: 88-96). Recent studies from our group reveal that AML cells produce ROS and down-regulate cell-mediated anti-leukemic immunity (Blood 119: 5832-7). In AML immunotherapy, HDC is administered in conjunction with IL-2 to achieve optimal NK and T cell activation.
Job assignments
The applicant will explore the role of Tregs in HDC/IL-2 immunotherapy in AML using experimental in vivo models, in vitro experiments, and clinical samples from patients undergoing HDC/IL-2 immunotherapy.
Eligibility
Applicants must have a Ph.D. in the fields of medicine, biomedicine or biology and less than three years of postdoctoral experience, counting from the application deadline. In case of special grounds, applicants that have completed their Ph.D. earlier may also be considered.
Assessment
The applicant should have a background in immunology, microbiology with orientation towards immunology, hematology, or oncology. Experience of flow cytometry and experimental animal models is desirable.
For further information please contact:
Kristoffer Hellstrand, Professor, MD
• 46 31 788 6672
kristoffer.hellstrand@microbio.gu.seLabour union
OFR/S: Stefan Schedin
• 46 31-786 1167
stefan.schedin@socav.gu.seSACO: Martin Björkman
• 46 31-786 3608
martin.bjorkman@amm.gu.seSEKO: Lennart Olsson
• 46 31-786 1173
lennart.olsson@gu.seClosing date 2013-04-02
Appointment Procedure
Please apply online,
www.gu.se/ledigaanstallningarThe application should contain:
• A cover letter giving a brief description of previous research experience, and a motivation to why you are applying
• A CV including a list of publication,
• Contact details of two references
The University of Gothenburg promotes equal opportunities, equality and diversity.
Salary is determined on an individual basis.
Applications will be destroyed or returned (upon request) two years after the decision of employment has become final. Applications from the employed and from those who appeal the decision will not be returned.
Publiceringsdatum2013-02-11Arbetstider och omfattningVisstidsanställning 6 månader eller längre
Heltid
Fixed-term employment, 2 år
ErsättningFast lön
Så ansöker duSista dag att ansöka är 2013-04-02
Ansökan kan tyvärr inte göras via e-post.
FöretagGöteborgs universitet
AdressGöteborgs universitet
Box 100
40530 GÖTEBORG
KontorsadressRenströmsgatan 6
Övriga kontaktuppgifterTelefonnummer: 031-7860000
Faxnummer: 031-7861119
Jobbnummer 1463770
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