Postdoctoral fellow in genotypic and phenotypic studies

Göteborgs universitet / Apotekarjobb / Göteborg
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Publiceringsdatum
2016-09-13

Beskrivning av verksamheten
The University of Gothenburg tackles society's challenges with diverse knowledge. 37 000 students and 6 000 employees make the university a large and inspiring place to work and study. Strong research and attractive study programmes attract scientists and students from around the world. With new knowledge and new perspectives, the University contributes to a better future.

Dina arbetsuppgifter
Enterotoxigenic Escherichia coli (ETEC) bacteria are the most common cause of diarrhea worldwide. ETEC are highly diverse, producing several different toxins, colonization factors (CFs) and O antigens. Our research group has developed a vaccine against such bacteria. The vaccine is based on a toxoid along with the most prevalent ETEC CFs. To evaluate if the vaccine is broad enough; i.e. protects against a majority of the clinical ETEC infections, it is of great importance to search for additional antigens (specifically CFs, but also other specific ETEC antigens) that need to be added in future ETEC vaccines. The post-doctor will identify and characterize novel ETEC CFs and other ETEC specific antigens in ETEC isolate collected from humans using "state of the art" genomic and phenotypic methods. At least 30% of ETEC bacteria causing diarrhea in humans lack a known CF. Furthermore, no ETEC specific antigens have been identified so far. Molecular studies of ETEC toxins and epidemiological studies on the prevalence of the novel ETEC antigens which will be discovered within the project will also be part of the project plan. Job assignments: Identify and characterize the above mentioned antigens in a collection of carefully selected ETEC isolates from the GU ETEC strain collection (~4000 isolates) using whole genome sequencing and advanced bioinformatic analyses. Construct mutants where the identified CF operons have been deleted for further analysis. Search for CF receptors/binding structures in different cell lines, intestinal biopsies and glyco-conjugates. Additional assignments: Animal (mouse) studies to characterize ETEC toxins and other antigens, transmission electron microscopy imaging, proteomics, transcriptomics, ETEC diagnostics (PCR and phenotypic).

Utbildning och erfarenhet
Eligibility: An achieved doctoral degree is compulsory for a position as postdoctor at Göteborg University. The doctoral thesis shall be in a relevant area according to the specific position stated here. Since a position as postdoctor aims to give new holders of the doctorate the opportunity mainly to strengthen and develop their scholarly proficiency, we aim for those who have a doctoral degree not older than 3 years counting from last date of application. The qualifications for academic positions are given in Chapter 4, Section 3 - 4 of the Higher Education Ordinance. Assessment: Achieved a PhD within 3 years. Several publications in international journals. Knowledgeable and experienced in using the above mentioned methods. Excellent skills in communicating both verbally and in writing. Regulations for the evaluation of qualifications for academic positions are given in Chapter 4, Section 3 - 4 of the Higher Education Ordinance.

Varaktighet, arbetstid
Visstidsanställning 6 månader eller längre
Heltid
Fixed-term employment, 2 years Tillträde
As agreed

Ersättning
Fast månads- vecko- eller timlön

Så ansöker du
Sista dag att ansöka är 2016-10-03
Please apply online: Klicka på denna länk för att göra din ansökan . PER 2016/398. The application should contain: - A cover letter giving a brief description of previous research experience, and a motivation to why you are applying - A CV including a list of publications - Proof of completed PhD - Contact details of two references
Ange följande referens när du ansöker: PER 2016/398

Kontakt
Ann-Mari Svennerholm, Professor, +46 31 786 6202 ann-mari.svennerholm@gu.se

Företag
Göteborgs universitet

Adress
Göteborgs universitet
Box 440
40530 GÖTEBORG

Kontorsadress
Medicinaregatan 7B

Övriga kontaktuppgifter
Telefonnummer: 031-7860000

Jobbnummer
3045292

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Postdoctoral fellow in genotypic and phenotypic studies

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