Postdoc Position, Mölndal, Se, (ref Postdoc25)
AstraZeneca Mölndal / Biologjobb / Mölndal
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hela Sverige Postdoctoral Position: Mitochondrial Drug Metabolism and its Toxicological Relevance
Business Area Research and Development
Specialism Innovative Medicines, Department DMPK, Location Sweden (Molndal), Closing date for applications 29 April 2013
At AstraZeneca, we're constantly striving to make new discoveries. Discoveries that will make a meaningful difference to health globally. We already have an exceptional product pipeline, and everyone here has a part to play in making sure that pipeline fulfils its potential. This is your opportunity to join them - and to fulfil your own.
We have an exciting opportunity for a PhD scientist to embark on basic research in the area of mitochondrial metabolism and its potential link to toxicity and cell death. The goal of the research is to understand the fundamental role of key mitochondrial oxidative enzymes and their potential link to cell toxicity. This work will contribute to our understanding of the oxidative metabolism of drug compounds and their potential for toxicity.
The FAM3 superfamily, including the secreted FAM3B PANDER and FAM3C ILEI proteins, are an emerging class of drug targets involved in glucose homeostasis and cancer. Recent in-house data show that PANDER exhibit an unexpected novel non-cytokine-like fold, indicating that the FAM3 superfamily might represent an entirely new class of signalling molecules. The aim of the postdoctoral project is to investigate the function of PANDER by mode of action studies in cell-based assays and by identification of receptors through a new and exciting cross-linking technology as well as by protein crystallography. You'll work in an interdisciplinary environment with state of the art cell, protein, structure and mass spectrometry facilities.
Accountabilities/Responsibilities
Design and conduct novel research to investigate the role of drug metabolism in mitochondria for compounds showing cell toxicity
Interact and collaborate with scientists across internal disciplines as well as with external experts
Publish scientific papers and attend conferences to communicate novel findings to the research community.
Receive advanced training to enhance professional skills and research independence; acquire in-depth understanding of the basic research and drug discovery fields to develop ideas for future career pursuit
Minimum Requirements - Education and Experience
A PhD in cell and molecular biology
Skills & Capabilities
Excellent skills in mammalian cell culture and transfection techniques
Excellent skills in plasmid constructions and generation of transient/stable cell lines
Experience in subcellular fractionation and immunological techniques
Experience and understanding of cell toxicity and assay development
Understanding of the mechanisms related to apoptosis
Ability to design and carry out research independently
Strong written and oral communication skills
Ability to work effectively and collegially with colleagues and initiate collaboration
As one of the world's leading pharmaceutical companies, our business is focused on providing innovative, effective medicines that make a real difference in important areas of healthcare. What's more, we support and encourage our people in discovering their own potential...To read more and apply for this position - please use this link:
http://gs.globalsuccessor.com/fe/tpl_astrazenecaV2.asp?newms=sePubliceringsdatum2013-03-25Arbetstider och omfattningVisstidsanställning 6 månader eller längre
Heltid
ErsättningFast lön
Så ansöker duSista dag att ansöka är 2013-04-29
Ange följande referens när du ansöker: POSTDOC25
Ansökan kan tyvärr inte göras via e-post.
FöretagAstraZeneca Mölndal
AdressAstraZeneca Mölndal
43183 MÖLNDAL
KontorsadressPEPPAREDSLEDEN 1
MÖLNDAL
Övriga kontaktuppgifterTelefonnummer: 031-7761000
Jobbnummer 1503544
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