Postdoc Position, Mölndal, Se, (ref Postdoc24)
AstraZeneca Mölndal / Biologjobb / Mölndal
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hela Sverige Postdoctoral Position: Exploring FAM3 signalling pathways by novel chemoproteomics approaches
Business Area Research and Development
Specialism Innovative Medicines, Department Discovery Sciences. Location Sweden (Molndal)
Closing date 29 April 2013
At AstraZeneca, we're constantly striving to make new discoveries. Discoveries that will make a meaningful difference to health globally. We already have an exceptional product pipeline, and everyone here has a part to play in making sure that pipeline fulfils its potential. This is your opportunity to join them ? and to fulfil your own.
We have an exciting opportunity for you to perform academic, cutting-edge research in an industrial setting at Discovery Sciences, Reagents and Assay Development in Mölndal. You'll perform interdisciplinary research and have the opportunity to work with research scientists across our different capabilities and with external collaborators. The proposed project is expected to lead to high-quality publications and you?ll be encouraged to present the results of your work both internally and at international scientific meetings throughout the program.
The FAM3 superfamily, including the secreted FAM3B PANDER and FAM3C ILEI proteins, are an emerging class of drug targets involved in glucose homeostasis and cancer. Recent in-house data show that PANDER exhibit an unexpected novel non-cytokine-like fold, indicating that the FAM3 superfamily might represent an entirely new class of signalling molecules. The aim of the postdoctoral project is to investigate the function of PANDER by mode of action studies in cell-based assays and by identification of receptors through a new and exciting cross-linking technology as well as by protein crystallography. You'll work in an interdisciplinary environment with state of the art cell, protein, structure and mass spectrometry facilities.
Accountabilities/Responsibilities
Establish cell-based assays, including a PANDER glucose production assay
Perform cross-linking experiments based on the recently published TRICEPs technology and deconvolution of data using mass spectrometry based methods
Analysis of effect of PANDER mutants in biochemical and cell-based assay
Minimum Requirements - Education and Experience
A recent PhD in cellular biology, biochemistry or molecular biology
Strong track record of working with mammalian cell cultures, including functional characterization of cells and practical understanding of cell-based assay development and optimization
Skills & Capabilities
Experience from proteomics/mass spectrometry/recombinant protein production
Strong scientific track record as supported by published or accepted papers in well recognized peer-reviewed journals and presentations at scientific meetings
Strong passion and commitment to science and ability to work well in a multidisciplinary team
Diabetes or oncology expertise
Strong interpersonal, organizational and communication skills
Proven ability to independently design/execute incisive experiments and interpret results
As one of the world's leading pharmaceutical companies, our business is focused on providing innovative...
To read more and to apply:
http://gs.globalsuccessor.com/fe/tpl_astrazenecaV2.asp?newms=sePubliceringsdatum2013-03-25Arbetstider och omfattningVisstidsanställning 6 månader eller längre
Heltid
ErsättningFast lön
Så ansöker duSista dag att ansöka är 2013-04-29
Ange följande referens när du ansöker: POSTDOC24
Ansökan kan tyvärr inte göras via e-post.
FöretagAstraZeneca Mölndal
AdressAstraZeneca Mölndal
43183 MÖLNDAL
KontorsadressPEPPAREDSLEDEN 1
MÖLNDAL
Övriga kontaktuppgifterTelefonnummer: 031-7761000
Jobbnummer 1503543
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