Postdoc Fellow - Senescence-associated exosomes in IPF
AstraZeneca / Biomedicinjobb / Göteborg
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hela Sverige AstraZeneca is a global, innovation-driven biopharmaceutical business that focuses on the discovery, development and commercialisation of prescription medicines for some of the world's most serious diseases. We're proud to have a unique workplace culture that inspires innovation and collaboration. We believe in the potential of our people and you'll develop beyond what you thought possible.
The new R&D BioPharmaceuticals organisation brings together research and development teams, from discovery through to late-stage development for Cardiovascular, Renal & Metabolic (CVRM), Respiratory, Inflammatory and Autoimmune (RIA) therapy areas, and opportunistically for Microbial Sciences and Neuroscience.
You'll be in a global pharmaceutical environment but also exposed to strong rigorous academic science. For example, every postdoc has an external academic mentor to ensure we are working and publishing at the highest level in a field. What's more, you'll have the support of a leading academic advisor, who'll provide you with the guidance and knowledge you need to develop your career.
Our Respiratory, Inflammation and Autoimmunity team offers definitive expertise to colleagues as well as across continents to scientists and patients. You'll help respiratory patients in areas with medical needs that aren't being fully met, including chronic obstructive pulmonary disease, asthma and rheumatic disorders. We're tackling these diseases from three areas: lung immunity, lung epithelium, and lung remodelling/regeneration. Right now, we are a leading figure in inhaled drug development and our new Inhalation Centre in Gothenburg, Sweden coupled with our work in new modalities is set to extend that lead even further.
Idiopathic pulmonary fibrosis (IPF) is a fatal disease with few treatment options. The molecular etiology of IPF is poorly understood; however, cellular senescence, a process whereby cells take on an aberrant phenotype causing the release of excess pro-fibrotic and pro-inflammatory mediators, is increasingly believed to play a key role in this disease. This is an opportunity to engage in cutting-edge research that bridges the gap between molecular mechanisms and translational research, to understand the extent and impact of senescence in IPF. The research will take place at AstraZeneca's vibrant research campus in Gothenburg, Sweden, leveraging the extensive resources and expertise of the Respiratory research group. Further, the postdoc will benefit from close collaboration with the laboratory of Dr. Philip Molyneaux (Imperial College, London), an expert in clinical research in the area of fibrotic lung diseases.
Education and Experience required:
Essential:
* PhD in molecular and cell biology or similar area
* Ability to independently drive a research project through design, execution, and interpretation of critical experiments.
* A strong scientific track-record, as evidenced by publication in high quality peer-reviewed journals, oral and/or poster presentations at scientific meetings.
* Enthusiastic and motivated personality
* Strong oral and written communication skills
* Extensive in vitro technical competence, including primary cell culture
Desirable:
* Experience in senescence biology and respiratory diseases, especially IPF
* Competence in next generation sequencing (NGS) technologies, including hands-on and data analysis expertise
* Experience with in vivo models of respiratory disease
Skills and Capabilities required:
* Isolation, culture, and manipulation of primary cells
* Overexpression and knockdown techniques
* Ability to work independently; but also, to integrate within a multidisciplinary team as needed
* A range of in vitro skills, including: immunoblotting, exosome isolation and analysis, RNA expression analysis, live-cell imaging, flow cytometry, RNA-sequencing
This is a 3 year programme. 2 years will be a Fixed Term Contract, with a 1 year extension which will be merit based. The role will be based in Gothenburg, SE, with a competitive salary on offer. To apply for this position, please click the apply link below.
Advert opening date - 31st May 2019 / Advert closing date - 9th August 2019
AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law.
Varaktighet, arbetstid
Heltid Temporary
Publiceringsdatum2019-06-03ErsättningNot Specified
Så ansöker duSista dag att ansöka är 2019-06-20
Ange följande referens när du ansöker: R-046186
Klicka på denna länk för att göra din ansökanKontaktAstraZeneca UK
Emma.wood@astrazeneca.comFöretagAstraZeneca
AdressAstraZeneca
43183
43183 1480
KontorsadressPepparedsleden 1
Jobbnummer 4817461
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