Postdoc Fellow - Med chem of small molecule PPI stabilisation
AstraZeneca / Elektronikjobb / Göteborg
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hela Sverige AstraZeneca is a global, innovation-driven biopharmaceutical business that focuses on the discovery, development and commercialisation of prescription medicines for some of the world's most serious diseases. We're proud to have a unique workplace culture that inspires innovation and collaboration. We believe in the potential of our people and you'll develop beyond what you thought possible.
The new R&D BioPharmaceuticals organisation brings together research and development teams, from discovery through to late-stage development for Cardiovascular, Renal & Metabolic (CVRM), Respiratory, Inflammatory and Autoimmune (RIA) therapy areas, and opportunistically for Microbial Sciences and Neuroscience.
You'll be in a global pharmaceutical environment but also exposed to strong rigorous academic science. For example, every postdoc has an external academic mentor to ensure we are working and publishing at the highest level in a field. What's more, you'll have the support of a leading academic advisor, who'll provide you with the guidance and knowledge you need to develop your career.
As a world leader in cardiovascular, renal and metabolic medicines, we're always working on innovative new drugs that will change lives across the globe. To make that happen, we employ a small molecule and new modalities research and development strategy with three priorities: heart failure, diabetes and chronic kidney disease. You'll focus your efforts on making real progress toward slowing, stopping or curing some of the most aggressive diseases that face humanity today.
You'll help develop the first rationally-designed small-molecule stabilisers of protein-protein interactions, enabling an unexplored molecular mode of action and influencing the discovery of future innovative therapeutics. The project will be carried out in collaboration with the leading academic research group in the field of protein-protein interaction stabilisation (Dr Christian Ottmann, Eindhoven University of Technology).
We are offering a chemist the opportunity to come and work with us on the discovery, development and characterisation of small-molecule, drug-like stabilisers of protein-protein interactions (PPIs), which is a potentially disruptive drug discovery technology.
You'll apply the principles of medicinal chemistry to improve the activity and selectivity of these compounds and generate an understanding of the basic principles of PPI stabilisation, with the goal of enabling this molecular mode of action for broader application within drug discovery.
You will:
* Optimise the small molecule PPI stabiliser hits which we have identified
* Perform compound synthesis and purification in state-of-the-art medicinal chemistry labs
* Test the PPI stabilisation activity of the compounds synthesised in biophysical and biochemical assays (such as fluorescence polarisation and surface plasmon resonance)
* Analyse the assay data to build structure-activity and structure-selectivity relationships and subsequently generate novel compound ideas for synthesis and testing in an iterative fashion
* Identify suitable compound candidates for X-ray crystallography studies and use the structures generated to perform virtual screening and structure-based design to identify potential novel PPI stabilising chemotypes that can be tested in our biophysical assays
* Apply in silico methods to identify and design compounds for screening and subsequent medicinal chemistry optimisation
* Gain a deep understanding of the principles and practice of modern medicinal chemistry as practised in an industrial drug discovery setting
Education and Experience required:
Essential:
* PhD in chemical biology, medicinal/pharmaceutical chemistry or organic chemistry
* An interest in medicinal chemistry, chemical biology or drug discovery
Desirable:
* Experience with analyzing assay data and using the conclusions to propose novel compounds to improve compound potency/affinity
* Experience with/knowledge of at least one of the following: structure-based drug design, in silico modelling/compound docking, virtual screening
* Practical experience with biophysical methods (such as SPR) or biochemical plate-based assays (such as fluorescence polarization assays)
Skills and Capabilities required:
* Experience in preparative synthetic organic chemistry and related analytical techniques
* Strong organisational, communication (spoken and written English), interpersonal skills and the ability to work well in a team with scientists from a range of disciplines
* Proven record of research, as shown by publications in reputable scientific journals
This is a 3 year programme. 2 years will be a Fixed Term Contract, with a 1 year extension which will be merit based. The role will be based in Gothenburg, SE, with a competitive salary on offer . To apply for this position, please click the apply link below.
Advert opening date - 31st May 2019 / Advert closing date - 9th August 2019
AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law.
Varaktighet, arbetstid
Heltid Temporary
Publiceringsdatum2019-06-03ErsättningNot Specified
Så ansöker duSista dag att ansöka är 2019-06-20
Ange följande referens när du ansöker: R-046189
Klicka på denna länk för att göra din ansökanKontaktAstraZeneca UK
Emma.wood@astrazeneca.comFöretagAstraZeneca
AdressAstraZeneca
43183
43183 1480
KontorsadressPepparedsleden
Jobbnummer 4828033
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