PostDoc Fellow - Impact of gut-derived microbial metabolites
AstraZeneca Göteborg / Apotekarjobb / Mölndal
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hela Sverige PostDoc Fellow - Impact of gut-derived microbial metabolites including Short Chain Fatty Acids on B cell development, localization and function.
At AstraZeneca, we believe in the potential of people who share our passion for science. By thinking boldly and working collaboratively to pursue discoveries beyond imagination, you'll develop further and faster than you thought possible. We'll complement your drive and determination to meet unmet patient needs around the world with the inspiration and opportunities to enhance your niche expertise and build your skills. So if you're curious about what science can do, come and make a difference.
Our Respiratory, Inflammation and Autoimmunity team offers definitive expertise to colleagues across the business. You'll help patients in areas with medical needs that aren't being fully met, including chronic obstructive pulmonary disease, asthma and rheumatic disorders. Right now, we're a leading figure in inhaled drug development, and our new Inhalation Centre in Gothenburg, Sweden is set to extend that lead even further.
Main duties and responsibilities
Short-chain fatty acids (SCFAs), such as acetate, propionate and butyrate, are microbial metabolites that play an important role in immunological tolerance. SCFAs exert their effects partly via specific G-protein coupled receptors GPR41, GPR43 and GPR109A and regulate the function of dendritic cells (DC), T cells and epithelial cells. However, our knowledge about the impact of SCFAs on B cells and associated antibody responses is limited at present
You'll be part of a project that aims to study the role of SCFA signalling on human and murine B cell responses, both in vitro and in vivo. The project involves the use of genetically modified mouse strains, either lacking GPR43, or carrying the human orthologue. In combination with unique pharmacological tools these animals will be used to delineate the signalling cascades regulated by SCFAs in the context of humoral immune responses to specifically delineate the signalling cascades regulated by SCFAs in the context of humoral immune responses.
The project is a collaborative effort between AstraZeneca, the University of Glasgow and the Karolinska Institute. You'll drive the project in collaboration with investigators at these sites. Key responsibilities include designing, planning and performing experiments including: in vivo characterisation of GPR deficient and transgenic mice with a focus on development, localisation and function of B cell subsets; and in vitro human and murine B cell activation studies, metabolic pathway analysis and transcriptomics to identify novel signalling cascades regulated by SCFAs on specific B cell subsets.
You'll collate, analyse and present data to team members, co-supervisors and external collaborators. We'll also encourage you to author manuscripts, including reviews, design posters and attend scientific conferences.
Essential requirements
PhD and/or MD in immunology or a related subject
Strong background in cellular immunology, innate-adaptive cross-talk or mucosal immunology
In vivo experience relating to murine models of vaccination, allergy or autoimmunity
Expertise in multi-parameter flow cytometry
Experience of designing and performing functional cellular assays in vitro.
Desirable requirements
Experience in B cell biology
Experience of next generation sequencing (NGS) and pathway analysis
Strong publication record in peer-reviewed journals in the field of immunology
Strong communication skills (spoken and written English), and the ability to work well in a team.
AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law. AstraZeneca only employs individuals with the right to work in the country/ies where the role is advertised.
This is a 2 year Fixed Term Contract opportunity, plus 1 year which will be merit based. The role will be based at Gothenburg, Sweden with a competitive salary on offer
At AstraZeneca, we believe in the potential of people who share our passion for science. By thinking boldly and working collaboratively to pursue discoveries beyond imagination, you'll develop further and faster than you thought possible. We'll complement your drive and determination to meet unmet patient needs around the world with the inspiration and opportunities to enhance your niche expertise and build your skills. So if you're curious about what science can do, come and make a difference.
As a world leader in cardiovascular and metabolic medicines, we're always working on innovative new drugs that will change lives across the globe. To make that happen, we've divided our small molecule research strategy into three priorities: cardiac regeneration, islet health in diabetes and diabetic nephropathy. You'll focus your efforts on making real progress toward slowing, stopping or curing some of the most aggressive diseases that face humanity today.
Publiceringsdatum2017-03-27Så ansöker duSista dag att ansöka är 2017-04-17
Klicka på denna länk för att göra din ansökanFöretagAstraZeneca Göteborg
AdressAstraZeneca Göteborg
Pepparedsleden 1
43183 MÖLNDAL
KontorsadressPepparedsleden 1
Jobbnummer 3399519
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