Post-doc position in Infection and RNA biology
Sveriges lantbruksuniversitet / Biologjobb / Uppsala
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Department of Molecular Biology, Uppsala Post-doc position in Infection and RNA biology
www.slu.seThe role of small RNAs in host-pathogen interactions
A post-doc position is available in the RNA Biology Group at the Department of Molecular Biology/Swedish University of Agricultural Sciences (SLU)/Biomedical Center(BMC)/Uppsala.
The main aim of the research is to understand the role of small RNAs, i.e.microRNAs (miRNAs) and small interfering (siRNAs) in response to bacterial infection.
The genetically tractable social amoeba Dictyostelium discoideum is used as a model for these studies. Dictyostelium is a well-established model for host-pathogen interactions where a number of pathogenic bacteria have been shown to infect and multiply within the
amoeba in ways very similar to those in animal cells. Recently, we have identified a large number of small RNAs, including micro (mi)RNAs, inDictyostelium and demonstrated that their biogenesis is dependent on different RNA interference (RNAi) related genes (Hinas et al, 2007, NAR and unpublished).
The project aims at understanding the role of small RNAs and their associated proteins during bacterial infection. The effect of bacterial non-coding RNAs on infection will also be studied. In plants, small RNAs have been implicated in defense against bacterial infection but little is known about this process in animals. A number of different biochemical, molecular, and cell biological tools will be applied for these studies, e.g. infection of Dictyostelium cells where RNAi related genes have been disrupted, high through-put sequencing of small RNA and mRNAs from infected cells, targeted gene disruption, and localization studies using gene-fusion techniques and fluorescent microscopy. The findings
concerning the effect of small RNAs on bacterial infection in Dictyostelium will be investigated in animal cell lines, e.g. macrophages.
The successful applicant will be part of the Linneaus/Swedish Research Council supported center of excellence (URRC - Uppsala RNA Research Center) where thirteen research groups at Uppsala University and SLU, situated at the Biomedical Center (BMC), study
different aspects of RNA biology.
The applicant should hold a PhD and have a strong background in infection biology and/or molecular biology. Experience in bacterial infection of cultured host-cells is a great advantage. Also skills in RNA biology is an advantage but not required.
You must be able to work independently but also interact/collaborate with group members and collaborators. Strong written and oral English communication skills are required. The project involves national and international collaborations.
The application must include your CV, list of publications, previous research accomplishments (one page) and names and contact information of at least two academic
references. The position is for up to two years.
Form of employment: Temporary employment Extent: 100%
SLU is an equal opportunity employer.
We welcome your application marked with ref no
67/2011.
Please submit your
application to the Registrar of
SLU, P.O. Box 7070, S-750 07
Uppsala, Sweden or
registrator@slu.se no later
than February 10, 2011.
The application should be written in English.
For a comple advt:
www.slu.se/lediga-jobbPubliceringsdatum2011-01-12Arbetstider och omfattningVisstidsanställning 6 månader eller längre
Heltid
The position is for up to two years
ErsättningFast lön
Så ansöker duAnge följande referens när du ansöker: SLU ID 67/2011
Ansökan kan skickas till e-postadress:
Registrator@slu.seFöretagSveriges lantbruksuniversitet
AdressSveriges lantbruksuniversitet
Box 7070
75007 UPPSALA
KontaktuppgifterTelefonnummer: 018-671000
Jobbnummer 819353
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