Post Doc Cvgi Imed Dmpk, Biological Targets
AstraZeneca Mölndal / Kemistjobb / Mölndal
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hela Sverige AstraZeneca is a major international healthcare business engaged in the research, development, manufacture and marketing of prescription pharmaceuticals and the supply of healthcare services. But we're more than one of the world's leading pharmaceutical companies. At AstraZeneca, we're proud to have a unique workplace culture that inspires innovation and collaboration. Here, employees are empowered to express diverse perspectives - and are made to feel valued, energized and rewarded for their ideas and creativity.
Description of Opportunity:
We have an exciting opportunity for a biotransformation scientist/organic chemist/biochemist to join the Cardiovascular & Gastrointestinal (CVGI) Innovative Medicines (iMED) department. The selected candidate will embark on a research project in the reactive metabolite field. Formation of reactive metabolites from drug molecules and the covalent binding of these reactive metabolites to proteins are proposed to be involved in adverse drug reactions and constitute a safety risk for drug candidates under development. Chemical trapping and other reactivity studies have led to the identification of different types of reactive metabolites with propensity to react with biological nucleophiles. Although there is a good understanding about the formation of electrophilic reactive metabolites, there is less known about the biological nucleophiles and the nature of the small molecule-protein adducts.
The primary objective of the project is to identify biological nucleophiles that form covalent adducts with reactive metabolites formed via ?-carbon oxidation of tertiary amines, i.e. iminium ions and aldehydes. The secondary objective is to build structure activity relationships that can be used in drug design to prevent formation of iminium ions and aldehydes that are likely to covalently bind to biological macromolecules. This research will provide also an opportunity to work with (and influence) fellow scientists across other disciplines. The results of these studies will be shared internally and throughout the scientific community via meetings and through publications.
Minimum experience:
A PhD in one of the following areas:
DMPK with a focus on metabolite identification and biotransformation.
Organic chemistry, medicinal chemistry or bioorganic chemistry.
Analytical chemistry with a focus on analysis of peptides/proteins by LC/MS.
Biochemistry with a focus on structural characterization of the modified proteins and peptides obtained from protein digests.
Preferred experience/requirements:
Protein digestion & peptide analysis
LC/MS & mass spectra analyses
A working knowledge of reaction mechanisms that may be relevant to the generation and subsequent reactivity of reactive metabolites particularly those derived from tertiary amines.
A general understanding of organic and bioorganic chemistry, particularly as applied to the biotransformation of small organic molecules.
Impeccable English in writing and speech
Excellent communication and social skills
More information:
Main Supervisors:
Dr. Ulrik Jurva, Associate Principal Scientist, DMPK Design Leader, CVGI iMed DMPK.
Dr. Emre Isin, Associate Principal Scientist, DMPK Design Leader, CVGI iMed DMPK.
Dr. Lars Weidolf, Senior Principal Scientist, DMPK Center of Excellence, Global DMPK.
External advisor:
Prof. Virginia Tech, Department of Chemistry, Blacksburg, VA 24061, USA.
Welcome with your application no later than February 9, 2012.
Publiceringsdatum2012-01-19Arbetstider och omfattningVisstidsanställning 6 månader eller längre
Heltid
ErsättningFast lön
Så ansöker duSista dag att ansöka är 2012-02-09
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FöretagAstraZeneca Mölndal
AdressAstraZeneca Mölndal
43183 MÖLNDAL
KontaktuppgifterTelefonnummer: 031-7761000
Jobbnummer 1133295
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