Post Doc - Expanding druggable space
AstraZeneca Mölndal / Kemistjobb / Mölndal
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hela Sverige AstraZeneca is a major international healthcare business engaged in the research, development, manufacture and marketing of prescription pharmaceuticals and the supply of healthcare services. But we're more than one of the world's leading pharmaceutical companies. At AstraZeneca, we're proud to have a unique workplace culture that inspires innovation and collaboration. Here, employees are empowered to express diverse perspectives - and are made to feel valued, energized and rewarded for their ideas and creativity.
Project Title: Expanding druggable space to challenging targets by development of rules for macrocycle ADMET.
Post Doc Location: AstraZeneca R&D Mölndal, Sweden.
Description of Opportunity
We have an exciting opportunity for a medicinal chemist to join the Cardiovascular and Gastrointestinal (CVGI) Innovative Medicines (iMED) unit. There you will embark on a research project which aims to determine the molecular properties that allow oral availability of macrocycles, and potentially also other compound classes that lie outside Lipinskis' rule of 5. This will be achieved by ADMET profiling of a unique macrocyclic small molecule collection developed at the Broad Institute, the AstraZeneca compound collection and macrocycle drugs on the market. By formulation of rules for ADMET of macrocycles this fundamental and important research will create opportunities for development of orally available drugs that modulate challenging targets that have hitherto resisted drug development efforts.
Your activities will be focused on selection of sets of macrocycles that answer specific questions, in silico and in vitro studies of these sets as well as interpretation of results and formulation of rules for macrocycle ADMET. Your research will also give you the opportunity to work with (and influence) scientists across many disciplines and to publish results at conferences and in high impact peer-reviewed journals.
The role's major responsibilities
Use computational techniques to select sets of macrocycles for ADMET profiling, then carry out the profiling using in silico and in vitro methodologies.
Interpret results and formulate a set of rules for the molecular properties that govern macrocycle ADMET.
Develop skills at the interface between medicinal chemistry and DMPK, as well as understanding of the drug discovery and development process
Show strong initiative in developing ideas, and bringing them to functional use within AstraZeneca.
Interface with scientists from across many disciplines, in particular DMPK and medicinal and computational chemistry, while at the same time being able to work independently.
Communicate results both within AstraZeneca via global working groups and externally at meetings and through publications.
Minimum experience
A PhD in one or more of the following areas: Chemical biology, medicinal chemistry, computational chemistry or a related field;
Experience in generating, validating, interpreting and utilising structure activity relationships (SAR);
Experience in generating, modelling and forecasting experimental data.
For complete information about the role and how to apply please visit
www.astrazeneca.sePubliceringsdatum2012-10-08Arbetstider och omfattningVisstidsanställning 6 månader eller längre
Heltid
2 years
ErsättningFast lön
Så ansöker duSista dag att ansöka är 2012-11-14
Klicka på denna länk för att göra din ansökanAnge följande referens när du ansöker: MOL000000VN
Ansökan kan tyvärr inte göras via e-post.
FöretagAstraZeneca Mölndal
AdressAstraZeneca Mölndal
43183 MÖLNDAL
KontorsadressPEPPAREDSLEDEN 1
MÖLNDAL
Övriga kontaktuppgifterTelefonnummer: 031-7761000
Jobbnummer 1360214
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