PhD-position
Sveriges lantbruksuniversitet / Kemistjobb / Uppsala
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hela Sverige Department of Biomedical Science and Veterinary Public Health
The Department of Biomedical Sciences and Veterinary Public Health is part of the Faculty of Veterinary Medicine and Animal Science and is responsible for undergraduate and post-graduate education and research on pathology, pharmacology, toxicology, immunology, virology, bacteriology, food safety, parasitology and epizootology.
Development of transgenic Caenorhabditis elegans to understand drug resistance in parasitic roundworms
Description:
We are looking for a PhD student in the subject field biomedical sciences, with a special focus on molecular parasitology. Resistance against anthelmintics (worm-specific drugs) is well established problem among parasitic worms of livestock but is also an emerging problem in human medicine. The large intestinal roundworms (Ascaridida) such as equine parasite Parascaris univalens, porcine parasite Ascaris suum, poultry roundworm Ascaridia galli and human parasite Ascaris lumbricoides is of concern for animal and human health. Currently no in vitro model is available for pathogenic roundworms.
Our hope is that the knowledge from this project will generate novel understanding about molecular biomarkers, to be applied in sustainable control programs for monitoring anthelmintic resistance in ascarid roundworms of horses, livestock and humans. Moreover, the C. elegans expression system for further studies of drug resistance in this parasite genera. This project is a collaboration between the Department of Biomedicine and Veterinary Public Health, Swedish University of Agricultural Sciences (SLU), and Department of Cell and Molecular Biology, Uppsala University (UU).
Tasks:
This is a molecular project with the aim to understand the molecular mechanisms of anthelmintic resistance by developing an in vitro transgenic lines of the free-living nematode Caenorhabditis elegans, using the equine roundworm, P. univalens, as a model worm of Ascaridida. Selected candidates genes, evaluated from RNA-seq data, from the horse roundworm is expressed in C. elegans. The transgenic C. elegans are exposed to increasing concentration of anthelmintic drugs and the function of candidate genes is studied in response to drug treatment.
Qualifications:
The applicant must meet the formal requirements to be admitted to PhD education at SLU. Adequate educational background could for example be a degree on master's level in the fields of molecular biology or biochemistry. Previous experience of molecular biology-methods and RNA-seq data is desirable, but not a requirement. A strong command of written and spoken English is essential. Excellent collaborative skills, high motivation and enthusiasm are important, as well as ability to work both independently and in a team. For this recruitment, candidates will mainly be ranked based on a qualitative evaluation of the candidate 's competence, skills, and judged capacity to successfully carry out a PhD education.
Place of work:
SLU, Uppsala
Forms for funding or employment:
Four year, employment as PhD student
Starting date:
According to agreement.
Application:
We welcome your application in English or Swedish no later than 2019-06-10. Start of project autumn 2019. Apply by use the button below.
A person has basic eligibility for third cycle education if he or she has taken a second cycle qualification or has completed course requirements of at least 240 higher education credits, including at least 60 higher education credits at second cycle education. Upper secondary school grades equivalent to English B/English 6 are a basic requirement.
Selection among applicants meeting the requirements is made with reference to written application including curriculum vitae, copies of degrees and transcripts of academic records, one copy of the dessertation for masters or undergraduate degree, a list of at least two references familiar with the applicant's qualifications, certified knowledge of the English language and an interview.
Please observe that applicant/s chosen to participate in an interview shall hand in certified true copies of certificates, diplomas and transcripts from previous studies at an internationally recognized higher education institution (university or university college) and transcripts in connection to the interview. If the applicant is a foreign citizen we require a certified copy of the page in your apssport with your personal data and phograghy.
Read about the PhD education at SLU at
www.slu.se/en/education/postgraduate-studies/Academic union representatives:
https://internt.slu.se/en/my-employment/employee-associations/kontaktpersoner-vid-rekrytering/The Swedish University of Agricultural Sciences (SLU) develops the understanding and sustainable use and management of biological natural resources. The university ranks well internationally within its subject areas. SLU is a research-intensive university that also offers unique degree programmes in for example rural development and natural resource management, environmental economics, animal science and landscape architecture.
SLU has just over 3,000 employees, 5,000 students and a turnover of SEK 3 billion. The university has invested heavily in a modern, attractive environment on its campuses in Alnarp, Umeå and Uppsala.
www.slu.se SLU is an equal opportunity employer.
Varaktighet, arbetstid
Heltid/ Ej specificerat
Publiceringsdatum2019-05-13ErsättningFixed salary
Så ansöker duSista dag att ansöka är 2019-06-10
Klicka på denna länk för att göra din ansökanKontaktEva Tydén, Forskare
fornamn.efternamn@slu.seStaffan Svärd, Professor
firstname.surname@icm.uu.seAndrea Hinas, Forskare
firstname.surname@icm.uu.seFöretagSveriges lantbruksuniversitet
AdressSveriges lantbruksuniversitet
Box 7036
75007 Uppsala
KontorsadressUlls väg 26
Jobbnummer 4784476
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