PhD student position in medical science - Mitochondria and perin
Göteborgs universitet / Administratörsjobb (offentlig verksamhet) / Göteborg
Observera att sista ansökningsdag har passerat.
Visa alla administratörsjobb (offentlig verksamhet) i Göteborg,
Mölndal,
Partille,
Kungälv,
Lerum eller i
hela Sverige Visa alla jobb hos Göteborgs universitet i Göteborg,
Partille,
Lysekil,
Uddevalla,
Vänersborg eller i
hela Sverige Publiceringsdatum2015-10-28Beskrivning av verksamhetenThe University of Gothenburg tackles society's challenges with diverse knowledge. 37 000 students and 6 000 employees make the university a large and inspiring place to work and study. Strong research and attractive study programmes attract scientists and students from around the world. With new knowledge and new perspectives, the University contributes to a better future.
Dina arbetsuppgifterType of employment: Fixed-term employment, 4 år Extent: 100 % Location: Sahlgrenska Academy, Gothenburg First day of employment: As agreed Reference number: UR 2015/906 Project title: Targeting mitochondria as therapeutic strategy for preventing perinatal brain injury. Job assignments: Perinatal complications, including asphyxia and preterm birth, are often associated with subsequent neurological deficits such as cerebral palsy (CP). Understanding the mechanisms triggered by insults to the immature brain will lead to the development of new strategies for the prevention and treatment of CP and other neurological deficits. Our hypothesis is that mitochondria-mediated neuronal cell death is the central process in perinatal brain injury. The current project will focus on the role of the mitochondria related protein, apoptosis inducing factor (AIF), in perinatal brain injury. The project includes several distinct but closely related aims that will study different aspects of mitochondria functions in relationship with brain injury. The focus will be on the impact of regulation mitochondrial metabolism on neonatal brain injury in animal models, the role of inflammation and autophagy on mitochondria dysfunction and brain injury, as well as the role of AIF release in neuronal cell death and brain injury. We will apply conditional gene deletion approaches to assess the role of AIF in perinatal brain injury. Furthermore, a unique gene knock-out strategy will be used to modulate AIF release and thereby acquire specific information on the importance of AIF release from mitochondria to the cytosol. Finally, the neuroprotective efficacy of a peptide will be evaluated which prevents AIF translocation to the nucleus, wher e it induces DNA degradation. The project will help to gain new insights for understanding the pathogenesis of perinatal brain injury and lead to the discovery of new prevention / neurprotective strategies. We would like the applicants to motivate why they interested in the project and why they are suitable applicants. The PhD position comprises 4 years full-time studies and leads to a doctoral degree. The position is funded via doctoral studentship.
Utbildning och erfarenhetTo be admitted to third-cycle studies you must fulfill both the general and the specific entry requirements. The general entry requirements is fulfilled if you have: 1. completed a degree at a second-cycle level, or 2. completed at least 240 credits worth of studies of which at least 60 credits must be at a second-cycle level, or 3. acquired equivalent knowledge in some other way in Sweden or abroad. The specific entry requirements is fulfilled if you have completed the English B/6 course or is considered to have acquired equivalent knowledge through previous studies.
Varaktighet, arbetstid
Visstidsanställning 6 månader eller längre
Heltid
TillträdeAs agreed
ErsättningFast månads- vecko- eller timlön
Så ansöker duSista dag att ansöka är 2015-11-23
Appointment procedure: Please apply online at the University of Gothenburg job application portal:
Klicka på denna länk för att göra din ansökanKontaktChanglian Zhu, Institute of Neuroscience and Physiology, Project supervisor
changlian.zhu@neuro.gu.seFöretagGöteborgs universitet
AdressGöteborgs universitet
Box 100
40530 GÖTEBORG
KontorsadressVasagatan 33
Övriga kontaktuppgifterTelefonnummer: 031-7860000
Jobbnummer 2501739
Observera att sista ansökningsdag har passerat.