Molecular Biomarker Lead
AstraZeneca AB / Biomedicinjobb / Göteborg
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hela Sverige Are you a curious Biomarker Scientist who wants to join a team working with outstanding science that have a direct impact for the patients? Do you also want to contribute to our larger purpose with great colleagues by your side working in a collaborative, global environment? If yes, this is the position for you!
We are now recruiting a Molecular Biomarker Lead who will play an important part in our Translational Science and Experimental Medicine (TSEM) organization within Early Respiratory and Immunology (R&I). Within TSEM, we are working in an open environment with a strong science focus and our work bridges the science with clinical development. This position can be based on our AstraZeneca site in Gothenburg (Sweden) or Gaithersburg (US).
Our Early R&I Translational Science and Experimental Medicine (TSEM) department is an agile environment with a science focused culture. Our mission is to understand disease mechanisms at the molecular level, identify the most effective target and the right patient population and close the gap between bench science and bedside clinical practice. One of our key remits is the development of biomarkers to drive patient segmentation, demonstrate target engagement, guide dose selection and bridge to clinical outcome. As a molecular Biomarker Scientist you are accountable for discovery of respiratory and immunologic disease precision and target engagement biomarkers and their development and validation specifically, but not limited to, the fields of transcriptomics and proteomics.
What you will do?
As a Molecular Biomarker Lead, you have significant experience in the invention and discovery of novel biomarkers and you are accountable for discovery and functional validation of respiratory and inflammation precision medicine genetic and molecular biomarkers. In this role you will be recognized as a specialist in molecular biomarkers and function as a key member of development teams and drive innovation in the Biomarker Discovery team through internal scientific development and external collaborations. You will raise AstraZeneca's scientific visibility through publishing scientific papers and presenting data at conferences.
The role will entail and require experience and understanding in the following areas:
• Experience in the invention and discovery of novel biomarkers
• A broad understanding of opportunities and limitations of NGS (next-generation sequencing) technologies in the context of biomarker discovery
• Experience and understanding of DNA and RNA manipulation for biomarker discovery
• Experience in establishing novel molecular biology techniques to identify biomarkers
• Responsibility for design, execution, interpretation and reporting of molecular based biomarker studies
• Use of clinical tissue to identify and validate biomarkers
Depending on your previous experience, your initial career level will be a Senior Scientist or an Associate Principal Scientist.
Essential for the role:
• PhD or equivalent within relevant field
• Experience in biomarker implementation preferably in biopharmaceutical clinical study
• Track record of delivering state-of-the-art biomarkers to projects in discovery and/or development setting
• Proven experimental drive and background in basic science related to respiratory and/or immunology research
• Technical expertise in specific biomarker discovery and analysis platforms including but not limited to - genomics, transcriptomics, epigenomics, NGS, proteomics, etc
• Knowledge of the biological basis for patient segmentation and precision medicine
This role requires that you are familiar with biomarker invention and implementation and that you have a strong publication record. Furthermore, you have in depth understanding of the drug discovery and development process from lead identification through clinical trials.
The successful candidate is also a truly motivated scientist with a passion to make a difference for patients all over the world. Along with this we see you as a person who enjoys team work and networking and is a good colleague to all. This goes hand in hand with your problem-solving and communication skills.
Desirable for the role:
• Significant experience in the development and deployment of next generation sequencing methods
• Post-doc experience in a relevant field
• Experience in pharmaceutical R&D
• Experience and deep understanding of respiratory and immunological disease biology including understanding of molecular pathways and mechanisms
Why AstraZeneca?
At AstraZeneca we're dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. There's no better place to make a difference to medicine, patients and society. An inclusive culture that champions diversity and collaboration. Always committed to lifelong learning, growth and development.
So, what's next!
If this sounds like an exciting career opportunity - apply today!
We look forward to getting to know you better and welcome your application as soon as possible, but no later than January 31, 2024.
Where can I find out more?
Follow AstraZeneca on LinkedIn
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Så ansöker du Sista dag att ansöka är 2024-01-31
Klicka på denna länk för att göra din ansökan Arbetsgivarens referens Arbetsgivarens referens för detta jobb är "R-188953".
Omfattning Detta är ett heltidsjobb.
Arbetsgivare Astrazeneca AB (org.nr 556011-7482)
Arbetsplats AstraZeneca
Kontakt AstraZeneca
karolina.zingmark@astrazeneca.com Jobbnummer 8381469
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