Modelling & Simulation Scientist at AstraZeneca
Proffice Life Science AB / Biologjobb / Göteborg
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hela Sverige We are looking for a Modelling & Simulation Scientist for an 9 months assignment at AstraZeneca. This temporary role as Modelling & Simulation (M&S) scientist will help provide projects with understanding and integration of the correlation between in-vitro and in-vivo ADME properties and the relationship between pharmacokinetics (PK) / toxicokinetics (TK) and pharmacodynamic (PD) responses including biomarkers for mechanism of action.
Business: Proffice Life Science
City: Göteborg
Deadline for applications: 2013-11-05
More information: Eleonor Ehrman 0733-434109 or Camilla Bågenholm 0733-434777
Major responsibilities:
• Define and deliver on the preclinical and translational PKPD strategy for efficacy and safety, in projects from prior to Target Identification to LCM
• Design preclinical and forward/backward translational PKPD and TKPD studies and report results and interpretations to project teams
• Deliver drug-drug interaction predictions and risk assessments to project teams
• Contribute to estimation of safety margins and make recommendations and predictions on human efficacous dose and exposure
• Evaluate and interpret PKPD and TKPD data to prepare for internal governance bodies
• Work collaboratively with other functions as needed to deliver the above (eg bioscientists, translational scienctists, safety scientists clinical pharmacologists and pharmacometricians).
• Document the work according to AstraZeneca GLS standards
• Contribute proactively to a vibrant and innovative working environment where improvements and new ideas are adopted and freely shared.
Key Deliverables
Deliver the PK, DDI, PKPD and TKPD elements to project teams within the agreed timelines and to the right quality
Minimum Requirements:
• PhD or equivalent experience in quantitative PK and PD related modelling & simulation of biological systems, ideally in preclinical/translational setting
• Track record of defining quantitative modelling strategies
• Track record of ability to meet timelines to pre-specified quality and cost
• Specialist in modelling and simulation tools such as WinNonLin/Pheonix, Matlab, SIMCYP
• Understanding of integrative aspects of DMPK and pharmacology/safety aspects of drug discovery and development
• Experience in pharmaceutical R&D
• Experience in operating cross-functionally
Skills and Capabilities
• Passion for Customers
• Thinks Strategically
• Acts Decisively
• Drives Performance
• Works Collaboratively
• Develops People and Organisation
Organization/Business description:
Proffice Life Science is the leading Nordic specialist of temporary recruitment services within the Biotech and Chemtech industries. We are able to provide our Nordic clients with highly skilled and experienced specialists from all over Europe.
All consultants, employed by Proffice, are specialists. Proffice is one of the largest and most well-renowned staffing agencies in Sweden. All consultants, hired by Proffice, have secure and permanent employment contracts with a certified staffing agency. We offer excellent benefits and personal development opportunities within a wide range of positions and industries.
Our clients expect only the best from Proffice and we expect only the best from our consultants. As you will spend your working day on our clients' premises, you will have to not only be an expert in your field, but also a flexible, independent and social member of the team. You thrive on new challenges and welcome new opportunities. If this appeals to you, we offer a stimulating job, with excellent benefits such as private medical insurance, discounted gym membership and further contributions to health care related activities.
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Publiceringsdatum2013-10-29Så ansöker duSista dag att ansöka är 2013-11-05
Ange följande referens när du ansöker: 200510473
Ansökan kan tyvärr inte göras via e-post.
Klicka på denna länk för att göra din ansökanKontaktEleonor Ehrman
FöretagProffice Life Science AB
AdressProffice Life Science AB
Jobbnummer 1689284
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