Modelling and Simulation Scientist to AstraZeneca
Alten Sverige AB / Biomedicinjobb / Göteborg
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hela Sverige About AstraZeneca
AstraZeneca is a global, innovation-driven biopharmaceutical business that focuses on the discovery, development and commercialization of prescription medicines for some of the world's most serious diseases. But we're more than one of the world's leading pharmaceutical companies. At AstraZeneca, we're proud to have a phenomenal workplace culture that encourages innovation and collaboration. Here, employees are empowered to express diverse perspectives - and are made to feel valued, energized and rewarded for their ideas and creativity.
We are looking for a motivated and mathematically inclinded individual to take on take on the role as Drug Metabolism and Pharmacokinetics (DMPK) Modelling and Simulation (M&S) Scientist for 12 months. As a DMPK M&S scientist you will be providing project teams with directions for applying computational biology and mathematical modelling approaches to predict efficacious dosage in human populations. This is be done by evaluation of pharmacokinetic/pharmacodynamic (PKPD) relationships in the context of mainly respiratory disease through integration of biological data from various sources. You will work closely with the biologist and collegues in the DMPK deprtment in drug discovery and development projects.
You are expected to have askill in mathematical modelling and an understanding of biology. In addition, you are expected to independently gather the information that you need for your work and have the aspiration and ability to quickly learn new scientific aspects of DMPK.
Main Duties and Responsibilities:
• The overall responsibility is to develop and execute translational PKPD strategies in drug projects from the point of target selection up to Phase 2 clinical trials. This means setting up mechanistic PKPD models that accommodate, to an appropriate level, established knowledge and working hypothesis of the target and disease biology. These will be progressively developed and refined to include definitions of the extent of drug target engagement that is anticipated to be required to see efficacy in Phase 2 trials, hence underpinning the human dose prediction. In achieving this goal you are likely to encounter and develop the following elements.
• Develop and apply physiologically-based pharmacokinetic models for various inhaled drug modalities.
• Collaborate with drug project biologists to articulate the drug project hypothesis by means of constructing a mathematical model. Use this model to evaluate hypothesis around target/disease biology with particular focus on defining quantitative relationships between drug exposure, target engagement and downstream biomarker changes.
• Develop and apply physiologically-based pharmacokinetic models for various inhaled drug modalities.
• Proactively, leverage and integrate public and proprietary clinical and non-clinical data from various sources, and suggest experiments that can provide key missing elements for the PKPD models.
• Make predictions of therapeutic dosing regimens in human by suggesting the anticipated human dose, dosing interval or timing in relation to disease progression or key events.
• Conduct bespoke PK data analysis including prediction of drug-drug interactions and whole body physiologically based PK (PBPK) modelling.Prepare clear presentations related to the above for internal governance bodies.
Requirements:
• Ph.D. or equivalent in Engineering, Mathematics, Physics or a related field, preferably with pharmaceutical industry experience.
• Knowledge and experience of physiologically-based pharmacokinetic/pharmacodynamic modelling.
• Expert in computer science and skilled in modelling tools such as R, Matlab etc.
• Aspiration to learn new scientific domains beyond mathematics and computer science to have ability to operate as DMPK generalist.
• Ability to engage and collaborate across boundaries with a problem solving attitude and focus on delivery
What we offer you at ALTEN
Every employee is equally valuable in the success of ALTEN! We are driven by making people grow and develop, which is why we offer you the opportunity to work with what you are truly passionate about. At ALTEN, we have a broad range of assignments at most of the leading companies in Sweden in several different sectors, to make it possible for your wishes to come true. We offer both national and international opportunities and together with your coaching manager, you build your career path so you constantly are able to develop and achieve your goals and dreams!
As a consultant at ALTEN, you will get the genuine team feeling at your assignment but also a wonderful togetherness at ALTEN. Through our different internal networks, such as ALTEN Sports, Women@ALTEN and ALTEN Innovation you will get the opportunity to drive topics and activities that are close to your heart, together with your colleagues. All activities are of course optional. Work life balance is our top priority. We also have a collective agreement and other benefits like Pension, Insurances and Wellness grants.
We believe in growing together!
Please note: Between 20th December and 8th January we will not be able to answer questions and no selection will be made during this period. Merry christmas and Happy new year!
Varaktighet, arbetstid
Heltid Tillsvidareanställning
Publiceringsdatum2019-12-20ErsättningEnligt överenskommelse
Så ansöker duSista dag att ansöka är 2020-01-15
Klicka på denna länk för att göra din ansökanFöretagAlten Sverige AB
Omfattning Detta är ett heltidsjobb.
Arbetsgivare Alten Sverige AB (org.nr 556420-7453)
Jobbnummer 5013612
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