Industrial PhD fellowship in computational drug design
Saromics Biostructures AB / Övriga jobb / Lund
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hela Sverige Visa alla jobb hos Saromics Biostructures AB i Lund SARomics Biostructures, Lund, Sweden and the Computational Receptor Biology group, Department of Drug Design and Pharmacology, University of Copenhagen wishes to employ a joint PhD Fellow in molecular modelling. The employment at SARomics Biostructures starts August 1st 2019.
SARomics Biostructures is one of the small fast-growing biotech companies in Lund. SARomics has attracted significant funding for its research programs and is currently involved in several international research initiatives aiming to discover leads for new medicines. In parallel the company has built a global reputation for its structural biology platform and its structure-based drug design skills and is currently supporting clients in Asia, Australia, Europe and North America to pursue their drug discovery objectives.
The Computational Receptor Biology group conducts bioinformatics, scientific data analysis and computational drug design, tightly integrated with leading chemists and pharmacologists, and structure-function studies of G protein-coupled receptors (GPCRs) - one of the largest drug target families.
Project
The PhD student will obtain ample scientific, business and transferrable skills at excellent research environments meriting him/her for an international academic or industrial career. The project will focus on structure based design of ligands with functional selectivity at the 5-HT2A receptor. The ultimate scientific goal is to gain molecular understanding and improve selectivity in treatments of CNS-related disorders. This will be done with a particular focus on the serotonin 5-HT2A receptor - the primary target for many pharmaceuticals and hallucinogens. The PhD fellow will design and prepare ligands for the receptor, generate and cross-interpret pharmacology and crystallographic data, and construct computational mechanistic models and databases that can explain and guide further experiments. This is fundamental to understand the biological and therapeutic effects, and to develop safer drugs.
Qualification requirements
Mandatory requirements
1. A MSc in in computational chemistry, bioinformatics or similar topic
2. Experience of data analysis related to G protein-coupled receptors
3. Demonstrated ability to independently learn new concepts and solve biological problems
4. Fluency in English and experience in writing scientific texts
5. The candidate must have less than 4 years of research experience and must not have resided or carried out his/her main activity in Sweden for more than 12 months during the last 3 years immediately prior to the recruitment
Additional meriting qualifications
Experience of, and skills in:
• Analysis of molecular structures and interactions
• The Schrödinger Drug Discovery Suite, PyMOL
• Shell scripting, programming in Python or other languages, and web development
Key criteria for the assessment of applicants
• Professional qualifications relevant to the project
• Relevant work experience
• Publications
• Other professional activities
• Language skills
• Good interpersonal skills
Application
The application, in English, must include a cover letter and the following appendices:
Appendix 1: curriculum vitae with documentation of education.
Appendix 2: a complete list of publications and list of submitted appendices.
Appendix 3: documentation of additional research qualifications.
Publiceringsdatum2019-04-01Så ansöker duSista dag att ansöka är 2019-04-22
Ange följande referens när du ansöker: PhD fellowship
FöretagSAROMICS BIOSTRUCTURES AB
KontorsadressSCHEELEVÄGEN 2
Jobbnummer 4703543
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