Expert in Cardiovascular Biomarkers Discovery and Development
AstraZeneca / Biologjobb / Göteborg
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hela Sverige Do you have expertise in Biomarker Discovery and Development in Cardiovascular and Metabolic Diseases? Would you like to apply your expertise at a company that are following the science and turn ideas into life changing medicines? Then you might be the one we are looking for!
We are now recruiting an Associate Principal Scientist, Biomarkers Discovery and Development to join the Biomarker team within Translational Science (TS) function in the Cardiovascular Renal and Metabolic Diseases (CVRM) therapeutic area at AstraZeneca in Gothenburg, Sweden.
CVRM is one of the three main therapeutic research areas within Innovative Medicines and Early Development (IMED), AstraZeneca's small molecule biotech unit that deliver candidate drugs into late-stage clinical development. CVRM TS has the remit to bridge pre-clinical, early and late drug development by providing early target validation in human and by driving precision medicine approaches through biomarker discovery and development based on understanding of human diseases and access to human patient samples. The biomarker team within CVRM TS is responsible for pre-clinical to clinical biomarker delivery which includes: (i) biomarker discovery for identification of target engagement and proof-of-mechansim biomarkers (ii) generation of target related precision medicine hypothesis (iii) analysis of explorative biomarkers in clinical projects and (iv) outsourcing decision-making biomarkers in clinical studies.
As an Associate Principal Scientist in the Biomarker team, you will play a key role in the clinical biomarker delivery and contribute to building the biomarker strategy to progress clinical projects and novel science. You will have the opportunity to try novel ideas and technologies, make judgements about complex scientific information, develop innovative solutions and applying comprehensive cross-functional understanding. You will also be responsible for outsourcing decision-making biomarkers according to Good clinical practise (GCP) as well as explorative biomarkers in the clinical projects, a process that involves CRO selection, Due Diligence process, contracts, assay validation, and sample monitoring.
Collaboration is critical for successful delivery of drug projects. You will thus work closely with scientists/teams from a wide range of different functions within AstraZeneca as well as with external partners and collaborators.
Essential Requirements
* Ph.D in a relevant scientific discipline and 3-5 years post-doctoral or industrial experience.
* Solid experience in biomarker discovery and development, preferentially within cardiovascular, renal and metabolism
* Expertise in a range of analytical techniques for biomarker analysis (proteins, peptides, lipids, small molecules), specifically immunoassay/ELISA platforms (MSD, Gyros, Luminex etc) and mass spectrometry
* Experience in outsourcing of biomarkers according to GCP in clinical studies including CRO selection, Due Diligence process, contracts, assay validation, and sample monitoring.
* Ability to plan and report all work to appropriate standards for outsourcing clinical biomarkers
* Problem solving mindset with the ability to identify issues, troubleshoot and design experiments to overcome difficulties and drive projects forward.
* Ability to maintain awareness of relevant areas of research, drug discover/development technologies and regulatory requirements through reading scientific literature and guidelines
* Passion for delivering and promoting excellence in science
* An excellent publication track record in the field
* Good project management and matrix leadership skills.
* Ability to collaborate and communicate well cross functions.
* Excellent English, both verbal and written
Desirable Requirements
* Working knowledge in biology of cardiovascular and metabolic diseases
* Experience of leading biomarker efforts aligned to drug discovery
* Experience of biostatistics, multivariate data analysis, and statistical learning
If you are interested, apply now!
For more information about the position please contact hiring manager: Pia Davidsson, +46 72 242 43 66 or
Welcome with your application no later than January 20th, 2019
AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law. AstraZeneca only employs individuals with the right to work in the country/ies where the role is advertised.
Varaktighet, arbetstid
Heltid Permanent
Publiceringsdatum2018-12-21ErsättningNot Specified
Så ansöker duSista dag att ansöka är 2019-01-18
Ange följande referens när du ansöker: R-041251
Klicka på denna länk för att göra din ansökanKontaktAstraZeneca
ulrica.marklund1@astrazeneca.comFöretagAstraZeneca
AdressAstraZeneca
43183
43183 1480
KontorsadressPepparedsleden 1
Jobbnummer 4524663
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