Doktorander/Utbildningsplatser
Sahlgrenska akademin vid Göteborgs universitet / Apotekarjobb / Göteborg
2012-01-20
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U 2012/33
Hypoxia related consequences of obstructive sleep apnea and nocturnal hypoxia
Application deadline: 2012-02-09
Description of the research project
Obstructive Sleep apnea (OSA) is a sleep related breathing disorder with a prevalence which exceeds 5 % amongst women and 20% in males in the age interval between 30-60 years. The condition is characterized by repetitive apneas, despite the effort to breathe, and is usually associated with repetitive episodes with reduced blood oxygen saturation (hypoxia) during sleep. Increased daytime sleepiness, impaired vigilance and cognition, as well as cardiovascular morbidity and mortality is associated and over-represented in patients with OSA. The pathophysiology of OSA is currently unknown. Recurrent apneas indicate that the respiratory and muscle regulating systems are unstable. Each apnea cycle leads to an alteration of oxygen/carbon dioxide concentrations in the body in a manner that subsequently paves the way for the next apnea cycle to occur. Hence, sleep is associated with hypoxia and increased levels carbon dioxide in various tissues in patients suffering from OSA. Continuous positive airway pressure (CPAP) represents a highly efficacious treatment in OSA, but the treatment effect is regularly somewhat hampered by limited compliance. Hypoxia and hypercapnia leads to metabolic adaptory changes in the body. These alterations are aimed to align cellular metabolism with energy supply. Such changes may be postulated to not only provide a predictable diagnostic marker of the degree of hypoxic exposure in patients with sleep apnea. They may also provide an explanation and a mechanism behind the disorder itself.
The aim of is this Phd-project is to map various regulatory mechanisms in relation to sleep apnea and to identify useful markers of disease. In particular there will be a focus on isoenzymes of the carbonic anhydrase family. Other targets include erythropoietin and vascular endothelial growth factor both in terms of circulating concentrations and gene expression. Systems involved in transcriptional induction of these target genes including the hypoxia-inducible factors (HIFs) will also be studied. In clinical terms both patients with sleep apnea and those with more severe nocturnal hypoventilation, e.g. those with severe chronic obstructive pulmonary disease or obesity hypoventilation syndrome will also be studied. These markers will be assayed in peripheral blood or in tissue, specifically fat tissue. Studies will include patients before and after treatment with pressure based ventilatory support during sleep.
For more information about the project, please contact main supervisor Jan Hedner, Institute of Medicine, email:
jan.hedner@lungall.gu.sePubliceringsdatum2012-01-20Arbetstider och omfattningVisstidsanställning 6 månader eller längre
Heltid
Så ansöker duSista dag att ansöka är 2012-02-09
Ange följande referens när du ansöker: "U 2012/33"
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FöretagSahlgrenska akademin vid Göteborgs universitet
AdressSahlgrenska akademin vid Göteborgs universitet
Box 400
40530 GÖTEBORG
KontorsadressMedicinaregatan 3
KontaktuppgifterTelefonnummer: 031-7860000
Jobbnummer 1135219
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