Doktorander/utbildningsplats
Sahlgrenska akademin vid Göteborgs universitet / Apotekarjobb / Göteborg
2011-05-10
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U 2011/293
Deciphering the role of Butyrophilin-like (Btnl) genes in gut immunity
Application deadline: 2011-05-31
Description of the research project
More than 50% of our immune system is located in the gut. The intestinal epithelium, which forms an interface between the organism and environment, harbors intraepithelial lymphocytes (IEL) which are mostly T cells with an unique cellular composition and development compared to other T cells in the body. The epithelial cells and the IEL represent an important barrier in the prevention of infection against orally acquired pathogens and thus, are critical effector component of mucosal immunity. However, the understanding of IEL function and their interaction, and the consequence of such interaction, with the neighbouring epithelial cells is still limited. Defining these interaction is crucial, not only to improve our understanding of the biology of T cells that reside in intestinal mucosa, but also to give new insights into the immune activation and perhaps more importantly, into immune dysregulation in infectious or autoimmune stress in the gut.
The overall aim of this project is therefore to characterize and understand the function of determinants that modulate immune responses of intestinal IEL and thus, to identify new molecular interactions involved in the IEL - epithelial cell cross-talk. The study will focus on novel immunoglobulin-like molecules, known as butyrophilin-like (Btnl) proteins, that are highly expressed by gut epithelial cells, and that by various criteria seem strong candidates for encoding novel immune regulators in the gut.
More specifically, this project aims to 1/ identify the expression, localization, and regulation of BTNL molecules and to understand their biochemistry 2/ investigate the capacity of BTNL to regulate IEL function by using a newly developed long-term IEL culture system which allows IEL interactions with intestinal epithelial cells to be examined 3/ characterize putative binding partners (ligands) for the BTNL proteins. Thus, this project provides the exciting opportunity to establish the functional role of BTNL-molecules in gut immunology, define a novel receptor-ligand interaction in gut T cell biology and improve our understanding of immune responses during gut inflammation and infectious stress.
Desired background
It is desirable that the student has a background in immunology and molecular biology and thus, is familiar with basic molecular and immunological techniques. Additionally, experience in cellular biology and biochemistry is beneficial.
For more information about the project, please contact main supervisor Anna Bas, Institute of Biomedicine, e-mail:
anna.bas@gu.sePubliceringsdatum2011-05-10Arbetstider och omfattningVisstidsanställning 6 månader eller längre
Heltid
Så ansöker duSista dag att ansöka är 2011-05-31
Ange följande referens när du ansöker: "Ref nr U 2011/293"
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FöretagSahlgrenska akademin vid Göteborgs universitet
AdressSahlgrenska akademin vid Göteborgs universitet
Box 400
40530 GÖTEBORG
KontorsadressMedicinaregatan 3
KontaktuppgifterTelefonnummer: 031-7860000
Jobbnummer 928985
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