Doctoral (PhD) student position in Neuropharmacology

Karolinska Institutet, Institutionen för klinisk neurovetenskap / Administratörsjobb (offentlig verksamhet) / Stockholm
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The Department of Clinical Neuroscience (CNS) conducts research and education in the field of neuroscience from the molecular level to the society level. The clinical research and education is conducted in collaboration with other research groups from the Karolinska Institutet, with other universities as well as the Stockholm County Council.
Please visit our website for more information: ki.se/en/cns



We are recruiting a student for doctoral education.

After a candidate is selected, an admission process commences. The candidate is admitted as a student once an individual study plan for the doctoral education has been approved by the departmental admission board.

For more information regarding doctoral (PhD) education, see: http://www.ki.se/doctoral.

Research group

The group study Parkinson 's disease and depression at a molecular and cellular level both in preclinical models and in specimens from patients. The goal is to identify novel targets for improved diagnostics and pharmacological receptor-based treatments. It is important for receptors to be properly located in nerve cell to properly activate relevant intracellular signaling cascades. The laboratory studies the dynamics of the localization and functionality of receptors. A working hypothesis is that altered levels of receptors in a certain compartment of a nerve cell can underlie pathology. In that respect experiments are focused on identifying and study adaptor proteins and lipids which bind to receptors and regulate their localization and function. Biochemical, histological, pharmacological, molecular biological and behavioral techniques are being used in the laboratory.

The doctoral education project and the duties of the student

This project is partly supported by a KI-NIH grant from the Karolinska Institutet. The focus is regulation of monoaminergic functions by trace amine-associate receptor 1 (TAAR1) with a special emphasis on Parkinson 's disease. The program uses a wide of methodologies including intracellular dynamics and signaling of molecules and their direct interactions or aggregation, studies of animal models and use of patient samples.

The studies relate to the role of GPCR-mediated processes in the etiologies of Parkinson's disease. Emphasis will be put on the role of a specific GPCR, called TAAR1 in the regulation of nigrostriatal circuits. In particular, it will be investigated the TAAR1's impact on the neurodegenerative process of dopamine neurons but also the basal ganglia network alterations in dopamine depleted states. Various molecular and cellular assays for enzymatic activities, receptor trafficking and signaling and function will be employed in vitro and in vivo. Successful applicants will generate data that guide the development of novel approaches to be tested in animal models of Parkinsonism. Independence and strong motivation are expected throughout the project. The student is expected to, under guidance, perform experiments, and analyze data as well as write reports and manuscripts in English.

Entry requirements for doctoral education at KI
To be eligible for doctoral education following requirements has to be met:

General entry requirements
A person meets the general entry requirements for doctoral/third-cycle/PhD education (according to Higher Education Ordinance Chapt 7, section 39) if he/she:

- has been awarded advanced/second-cycle/master qualification (i.e. master degree) or
- has satisfied the requirements for courses comprising at least 240 credits of which at least 60 credits were awarded in the second-cycle/master level, or
- has acquired substantially equivalent knowledge in some other way in Sweden or abroad.
Specific entry requirements
Proficiency in English equivalent to the course English B/English 6 at Swedish upper secondary school:
Proficiency in the English language can be documented by an internationally recognized test such as TOEFL or IELTS, see web-link below for more information.
Applicants who meet the general entry requirements (1 or 2 above) from a university in one of the Nordic countries fulfill the requirements in English.

For more information regarding general and specific entry requirements: http://ki.se/en/education/entry-requirements-eligibility-for-doctoral-education

Skills and personal qualities

The successful candidate should have a strong drive to pursue experimental research, and be ambitious and innovative. The project is pursued in collaboration with other researchers and good collaborative skills are necessary. Knowledge and experience in molecular neuropharmacology, preferably in the neurodegeneration field, is advantageous. Experience of working with transgenic mouse models (FELASA B certificate is considered as an advantage), protein biochemistry and molecular cell biology techniques, is a merit. Applicants must have experience of brain sectioning (cryostat sections) and staining with both in situ hybridization and immunohistochemistry techniques. Moreover, applicants need to have great knowledge of mammalian neuroanatomy (both rodent and human) of basal ganglia and related structures.

Please read more about the position and apply at https://ki.mynetworkglobal.com/en/what:job/jobID:203065/

Karolinska Institutet is one of the world's leading medical universities. Its vision is to significantly contribute to the improvement of human health. Karolinska Institutet accounts for the single largest share of all academic medical research conducted in Sweden and offers the country's broadest range of education in medicine and health sciences. The Nobel Assembly at Karolinska Institutet selects the Nobel laureates in Physiology or Medicine.
Pursuant to the regulations of the Swedish National Archives, applications are kept on file for two years after the appointment has gained legal force. The regulations do not apply to attachments that have been printed or otherwise published.
Karolinska Institutet strives to provide a workplace that has approximately the same number of women and men, is free of discrimination and offers equal opportunity to everyone.

For temp agencies and recruiters, and to salespersons: We politely, yet firmly, decline direct contact with temp agencies and recruiters, as well as those selling additional job announcements.

Varaktighet, arbetstid
100%. Tillträde: According to agreement Visstidsanställning

Publiceringsdatum
2018-04-19

Ersättning
Monthly salary

Så ansöker du
Sista dag att ansöka är 2018-05-10
Ange följande referens när du ansöker: 2-2254/2018
Klicka på denna länk för att göra din ansökan

Kontakt
Caisa Stilling, HR administrator + 46 8- 524 832 82
Xiaoqun Zhang, Assistant Professor xiaoqun.zhang@ki.se, + 46 8-517 746

Företag
Karolinska Institutet, Institutionen för klinisk neurovetenskap

Adress
Karolinska Institutet, Institutionen för klinisk neurovetenskap
Administrationen, Tomtebodavägen 18a, plan 5
17177 Stockholm

Kontorsadress
Administrationen, Tomtebodavägen 18a, plan 5

Jobbnummer
4094450

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