Computational Oligonucleotides Design Expert
AstraZeneca / Kemistjobb / Göteborg
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hela Sverige Are you a dedicated scientist with Oligonucleotide Design experience? Would you like to join a multi-disciplinary team of world-class scientists?
We are committed to the development of the next generation innovative respiratory medicines and want you to join us in our thrive to transform scientific excellence into development of new drugs. Our New Modalities (NMs) Chemistry team in Respiratory, Inflammation & Autoimmunity leads the efforts focused on rapidly growing the use of novel peptide and oligonucleotide-based modalities and molecular conjugates in the treatment of respiratory diseases. We achieve this in close collaboration with excellent scientists from interdisciplinary departments - all joined by the goal to discover the respiratory medicines of the future.
We offer a possibility for you to be part of the computational chemist team as an expert within Oligonucleotides Design. You and your colleagues are specialized on design of both SMs and NMs based therapeutics. As an authority in the field, you will contribute to the design of new oligonucleotide sequences to specific RIA projects.
Main Duties and Responsibilities
We expect you to design novel oligonucleotides and to influence the selection of portfolio targets by highlighting opportunities for therapeutic applications. You will be an active member of the RIA oligonucleotide projects from target selection to identification of clinical drug candidates. Working and navigating in our multidisciplinary environment as well as mentoring junior colleagues will give you the possibility to practice and develop your leadership skills.
* Lead oligonucleotide design in individual project teams
* Demonstrate state of the art oligonucleotide design options for both target validation and therapeutic use
* Analysis of mRNA/microRNA target sites for ASOs/siRNAs/antimiRs
* Identification of suitable mRNA sequence regions for RNAi (UTRs, coding regions)
* Identification and correlation of sequence and potency parameters for optimization
* Project specific display of sequence alignments and potency data
* Contribution to internal projects and collaborations with external partner organizations
* Drive our scientific reputation by publications as well as giving presentations internally and externally and in collaboration with external organizations
Essential Requirements
Your success in this role will depend of your ability to combine your deep scientific knowledge with excellent interpersonal skills. In addition, you have the ability to engage and collaborate across boundaries with a can-do attitude and a clear delivery focus.
* PhD in bioorganic chemistry, computational chemistry or bioinformatics
* Experience in pharmaceutical drug discovery of oligonucleotide drug candidates
* Validated in-depth knowledge of recent developments in oligonucleotide drug discovery
* Robust understanding of mechanism of action of oligonucleotide therapeutics (alternative splicing, steric blocking of protein translation, RNAaseH activity, RISC loading, splice switching, immune stimulation)
* Expertise in conformational/secondary/tertiary structure analysis of mRNA using state of the art software
* Expert user of ASO modeling software for e.g. prediction of ASO-target binding energies
* Experience in molecular dynamics simulations, preferably for NMs
* Basic knowledge in prediction of potential off-target interaction and toxicity
If you are interested, apply now!
For more information about the position please contact Dr. Werngard Czechtizky, Head of Medicinal Chemistry, IMED RIA at or via LinkedIn.
Welcome with your application no later than March 15th, 2019.
Information about life in Gothenburg:
www.movetogothenburg.com Respiratory is one of AstraZeneca's main therapy areas. Our aim is to transform asthma and COPD treatment through inhaled combinations at the core of care, biologics for the unmet needs of specific patient populations, and scientific advancements in disease modification.
From a research perspective we work to understand, treat, modify and ultimately cure respiratory disease with an emphasis on four diseases with significant unmet medical need; asthma, COPD, Idiopathic Pulmonary Fibrosis (IPF) and Chronic Cough. Recently, we reshaped our strategic focus into three mechanistic and complimentary areas in chronic lung disease: Lung Immunity, Lung Epithelium and Lung Regeneration.
Our Respiratory research is mainly carried out at the dynamic AstraZeneca Research site in Gothenburg, Sweden. However, collaboration is a way of life for us. Extensive collaboration with our AstraZeneca colleagues in Cambridge UK, the MedImmune research units in Gaithersburg and Cambridge, as well as numerous academic institutions and partners around the globe gives us access to a worldwide network of expertise and innovation.
AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law. AstraZeneca only employs individuals with the right to work in the country/ies where the role is advertised.
Varaktighet, arbetstid
Heltid Permanent
Publiceringsdatum2019-02-19ErsättningNot Specified
Så ansöker duSista dag att ansöka är 2019-03-19
Ange följande referens när du ansöker: R-045214
Klicka på denna länk för att göra din ansökanKontaktAstraZeneca
karin.lyckemalm@astrazeneca.comFöretagAstraZeneca
AdressAstraZeneca
43183
43183 1480
KontorsadressPepparredsleden 1
Jobbnummer 4622859
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