Biologics Dmpk Specialist
AstraZeneca AB / Biomedicinjobb / Göteborg
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hela Sverige Are you an experienced DMPK scientist with expertise in pharmacokinetics and translational PKPD modelling of antibody-based therapeutics? Would you like to apply your knowledge in a global company that follows the science and turns ideas into life-changing medicines? Then you could be the new colleague we are looking for!
Our team is growing, and we are now recruiting a motivated individual to join our DMPK department as a Preclinical DMPK lead within Early Respiratory and Immunology (R&I). Your level of professional experience will be relevant for your initial career level (Associate Principal Scientist or Principal Scientist). This position is placed at AstraZeneca's vibrant R&D site in Gothenburg, Sweden, one of AstraZeneca's three strategic science centres.
At AstraZeneca Early Respiratory & Immunology (R&I), we're proud to have an outstanding workplace culture that encourages innovation and teamwork. We are united by our vision to push the boundaries of DMPK science to transform ideas into medicines for R&I patients. Employees are empowered to express diverse perspectives - and are made to feel valued, energized and rewarded for their ideas and creativity.
What you'll do
You have in-depth knowledge of biologics drug discovery and a keen interest in understanding the translational PKPD of antibody-based therapeutics. In the role you would work collaboratively with discipline leads from other departments including Project Leaders, Biologics Engineering, Bioscience / Translational Science, Safety and Biopharmaceutical development. You will be responsible for designing and delivering the DMPK strategy to ensure project progression from target selection through to candidate drug selection / preclinical development.
Main Duties and Responsibilities
• Responsible for leading all DMPK related activities, including coordinating and engaging with internal and external DMPK colleagues and collaborators on project related activities
• Deliver DMPK input and data interpretation to projects to ensure that DMPK challenges are thoroughly assessed and resolved
• Ensure that translational PKPD approaches are embedded at the heart of project strategy and used to support design of appropriate experiments that are aligned to the strategy underpinning human dose prediction
• Develop excellent working relations with key stakeholders within both DMPK and in the project teams, to ensure strategic alignment, strong cross discipline collaboration and communication
• Responsible for preparing clear presentations of DMPK contributions to internal governance interactions for the projects you support
Essential for the role
• PhD (or equivalent industrial experience) in a relevant field eg. pharmacokinetics, pharmacology, biopharmaceutics etc
• Comprehensive understanding of biologics drug discovery, including the PK and PKPD of antibody based therapeutics
• Experience of DMPK project facing role in pharmaceutical R&D with a variety of therapeutic antibody formats (e.g. mAbs, Fabs, bispecifics, ADCs etc)
• Excellent interpersonal skills, and ability to work in cross-functional teams as well as independently
• Experience in developing translational PKPD strategies and mathematical modelling approaches in support of human dose predictions
• Hands on experience of PKPD modelling using specialist tools such as Phoenix / WinNonLin, MATLAB, R, Monolix, NONMEM or similar
This is an exciting opportunity for a talented DMPK scientist to join a strong team and support the portfolio of a major pharmaceutical company that has science at its heart whilst being based in the wonderful city of Gothenburg, Sweden.
Why AstraZeneca?
At AstraZeneca we're dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. There's no better place to make a difference to medicine, patients and society. An inclusive culture that champions diversity and collaboration. Always committed to lifelong learning, growth and development.
What's next!
If you are ready to make a difference - apply today, and we'll make it happen together! We welcome your application until May 21, 2023.
Where can I find out more?
Our Gothenburg site:
https://www.astrazeneca.com/our-science/gothenburg.htmlLife in Gothenburg:
https://www.movetogothenburg.com/Culture and atmosphere of the Gothenburg site:
https://www.linkedin.com/feed/update/urn:li:activity:6496327311678410752/Relocate to Gothenburg:
https://www.astrazeneca.se/om-oss/verksamheten-i-sverige/goteborg/relocate-to-gothenburg.html Ersättning Not Specified
Så ansöker du Sista dag att ansöka är 2023-05-18
Klicka på denna länk för att göra din ansökan Arbetsgivarens referens Arbetsgivarens referens för detta jobb är "R-164965".
Omfattning Detta är ett heltidsjobb.
Arbetsgivare Astrazeneca AB (org.nr 556011-7482)
Arbetsplats AstraZeneca
Kontakt AstraZeneca
karolina.zingmark@astrazeneca.com Jobbnummer 7712026
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