Associate Principle Scientist, Preformulation
AstraZeneca AB / Biomedicinjobb / Göteborg
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hela Sverige At AstraZeneca we turn ideas into life changing medicines and strive to continuously meet the unmet needs of patients worldwide. Working here means being entrepreneurial, thinking big, and working together to make the impossible a reality. If you are swift to action, confident to lead, willing to collaborate, and curious about what science can do, then you're our kind of person.
Pharmaceutical Sciences at AstraZeneca deliver the therapies of the future through scientific leadership in drug delivery, design of synthetic routes, and manufacturing of Active Pharmaceutical Ingredients (API) and drug products. Our portfolio of projects spans traditional small molecules, peptides, oligonucleotides to RNA based therapeutics across AstraZeneca's therapy areas. Advanced Drug Delivery (ADD) resides within Pharmaceutical Sciences with a mission to provide novel products to AstraZeneca's clinical pipeline.
We now seek a talented, motivated Preformulation Associate Principal scientist to join our team in Gothenburg, Sweden. It is a key scientific position that will lead formulation and delivery evaluation from discovery to clinical candidate nomination. The focus is the new modality and advanced drug delivery portfolio of oligonucleotides, RNA and peptides-based therapeutics with emphasis on peptides. We are looking for a candidate with previous experience in supporting peptide projects and who has a strong understanding of formulation, analytics, and parenteral drug delivery technologies. The role will be expected to work cross-functionally supporting drug projects and be involved with science & technology initiativesYou will be reporting to the preformulation team leader and collaborate closely with other ADD teams located in Waltham, US, Cambridge, UK and Gothenburg, Sweden.
Main duties and responsibilities
* Represent the CMC function in the preclinical research project team. Work as a member of cross-functional pharmaceutical project teams, with a large degree of independence representing own group and area of expertise.
* Plan resource, budget, timeline, and comprehensive CMC development strategy to enable rapid and high-quality drug development.
* Develop formulations, analytical methods, and delivery systems with a focus on peptides. Responsible for designing, planning and preparation of study protocols for preclinical studies Conduct biophysical characterization of peptides. Plan experiments and generate data clearly and reliably.
* Transfer preclinical formulation, characterization and analytical knowledge to clinical CMC groups or to external outsourcing partner in a concise and collaborative fashion.
* Engage in external technology evaluation. Collaborate with specialist scientific and/or technology networks.
* Represent the department in a cross-functional pharmaceutical project teams, with a large degree of independence. Develop expertise and continue to demonstrate scientific scholarship.
* Remain up to date with relevant internal and external developments that affect the company and function and share with other members of team or function.
* Ensure that own work and the work of others is performed in accordance with appropriate Safety, Health & Environment (SHE), quality, and compliance standards.
Essential Requirements
* PhD degree and post-doctoral experience in a relevant scientific discipline (e.g., Biochemistry, Pharmaceutics, Biotechnology, Biophysics, or Chemistry) or equivalent industry experience within the field of Pharmaceutical and Biotechnologies.
* Experience developing with biomolecules therapeutics (e.g., peptides or proteins) and the desire to explore other new modalities.
* Excellent communication and stakeholder management skills, and the ability to discuss complex ideas in a simple, easy to understand way.
* Strong influencing and prioritization skills to ensure project delivery
* Ability to tackle complex scientific problems and troubleshooting.
* Good understanding of the overall drug discovery and development process and an appreciation of how Pharmaceutical Sciences disciplines contribute to R&D
Desirable Requirements
* Ph.D. degree in a relevant scientific discipline (e.g. Biochemistry, Pharmaceutics, Biotechnology, Biophysics, or Chemistry)
* Minimum 5 years of industry experience focusing on biophysical or analytical characterization of proteins and peptide formulations and delivery systems.
* Experience of leading collaborative teams and/or project management
* Track record of scientific excellence in terms of publications, presentations and networking activities.
* Experience of managing external collaborations
* Confident, execution focused, and team oriented with an ability to thrive in an entrepreneurial environment.
If you are interested, apply now!
We will screen candidates continuously and we need your application at the latest February 16, 2020.
For more information about the role please contact Sara Richardson, Team Leader Advanced Drug Delivery +46725821650
Varaktighet, arbetstid
Heltid Permanent
Publiceringsdatum2020-01-21ErsättningNot Specified
Så ansöker duSista dag att ansöka är 2020-02-04
Klicka på denna länk för att göra din ansökanFöretagAstrazeneca AB
Arbetsgivarens referens Arbetsgivarens referens för detta jobb är "R-072069".
Omfattning Detta är ett heltidsjobb.
Arbetsgivare Astrazeneca AB (org.nr 556011-7482)
Arbetsplats AstraZeneca
Jobbnummer 5052093
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