Associate Principal Scientist Metabolism In Vivo Team
AstraZeneca AB / Kemiingenjörsjobb / Göteborg
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hela Sverige Are you an expert in in vivo pharmacology within the metabolic disease research area? Would you like to apply your expertise in a global company that is accelerating innovative science and turn ideas into life changing medicines? Join us to discover future treatment of Cardiovascular, Renal and Metabolic (CVRM) diseases!
Working at AstraZeneca means being entrepreneurial, thinking big and working together to make the impossible a reality. We are now recruiting a high caliber Associate Principal Scientist to join the in vivo metabolism bioscience team within Research and Early Development CVRM. The position is placed at AstraZeneca's dynamic R&D site in Gothenburg, Sweden.
CVRM is one of the three main therapeutic research areas within AstraZeneca which deliver candidate drugs into clinical development. CVRM Metabolism Bioscience department has a dynamic environment that fosters collaboration and innovation. We are a team of professionals who are passionate about advancing science, to discover and develop novel therapeutics that will benefit patients suffering from diabetes, obesity, NASH, cardiovascular and/or chronic kidney disease.
What you'll do
This is a both lab-based and project leadership role where you will provide scientific leadership through developing and leading scientific and technical capabilities required for progressing drug discovery projects within the metabolic disease area. You will provide key experimental data supporting multi-disciplinary project teams in Cambridge, Gothenburg and Gaithersburg.
Responsibilities include:
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You will be an expert in your area and play an active role in implementing and performing scientific research and development strategy within the metabolism department, enabling the prosecution of a rapidly growing portfolio of drug projects across multiple modalities.
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Be a "hands-on" expert and "lead from the bench" in vivo models and methodologies with an enthusiasm for laboratory work and scientific curiosity. Playing leading role in assay development and optimization of screening cascades in relevant in vivo disease models, being responsible for design, execution, analysis and communication of in vivo studies.
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Act as lead biologist and project leader for drug discovery projects.
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Act as a champion for novel approaches for drug discovery in metabolic disease area, promoting scientific debate within CVRM Research and playing a leading role in the selection and validation of new targets.
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Raise the scientific profile of CVRM both within AstraZeneca and externally through publications and presentations, as well as initiating or participating in external collaborations.
Essential for the role
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PhD in life sciences with relevant 5+ years postdoctoral experience with strong background in metabolic disease research areas with experience of diabetes, Obesity, dyslipidemia, NASH, or other liver diseases.
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Proven expertise in in vivo pharmacology and physiology and hands-on skills to develop models supporting AstraZeneca's discovery programs in metabolic diseases with essential expertise in surgical procedures and cannulation; as well as Drug metabolism and pharmacokinetics.
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Strong interest in problem solving through design and execution of complex in vivo mechanistic studies and robust expertise in data analysis, interpretation and data quality control.
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Evidence of scientific leadership recognised by publication record in leading peer reviewed journals, with enthusiasm to maintain a high external scientific profile through publication and conference presentations.
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Excellent organisational, time management, communication and interpersonal skills.
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Excellent English, both spoken and in writing.
Desirable for the role
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Experience of working within drug discovery projects in pharmaceutical or biotech environment with proven expertise in leading drug discovery projects
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Strong ability in leading several simultaneous projects/tasks
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Significant experience of numerous in vitro and ex vivo cell-based technologies for assessing signaling endpoints for multiple target classes (qPCR, Western Blots, Elisa).
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Metabolic clamp techniques in conscious and anesthetized animals, including the use of radiolabeled isotopes to assess nutrient fluxes
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Experience of writing ethical applications relevant in vivo models/studies
So, what's next?
Are you already imagining yourself joining our team? Good, because we can't wait to hear from you!
Welcome with your application no later than June 5th, 2022
Where can I find out more?
Our Gothenburg site: Link
Global Gothenburg: Link
Why AstraZeneca?
Our Gothenburg site is one of AstraZeneca's three strategic R&D centers. With more than 2,400 employees from over than 50 countries, our vibrant Gothenburg site is a truly inspiring place to work. Here, the history and future of scientific breakthrough come together. We believe that the diversity of our people is crucial to bringing new discoveries to life.
Varaktighet, arbetstid
Heltid Permanent
Publiceringsdatum2022-05-11ErsättningNot Specified
Så ansöker duSista dag att ansöka är 2022-06-08
Klicka på denna länk för att göra din ansökanFöretagAstrazeneca AB
Arbetsgivarens referens Arbetsgivarens referens för detta jobb är "R-138022".
Omfattning Detta är ett heltidsjobb.
Arbetsgivare Astrazeneca AB (org.nr 556011-7482)
Arbetsplats AstraZeneca
Jobbnummer 6632725
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