Associate Principal Scientist - Protac Medicinal Chemistry
AstraZeneca / Logistikjobb / Göteborg
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hela Sverige Are you a skilled Synthetic Chemist with experience of working with PROTACs? Are you ready to bring new ideas and fresh thinking to the table?
At AstraZeneca we turn ideas into life changing medicines and strive to continuously meet the unmet needs of patients worldwide. Working here means being entrepreneurial, thinking big and working together to make the impossible a reality. If you are swift to action, confident to lead, willing to collaborate, and curious about what science can do, then you're our kind of person.
This APS position is placed in the Department of Medicinal Chemistry of Respiratory, Inflammation & Autoimmunity (RIA) - right in the middle of AstraZeneca's vibrant R&D site in Sweden hosting around 2500 employees with a great diversity of scientific expertise and nationalities.
RIA 's Medicinal Chemistry department is working across small to large sized synthetically accessible therapeutic modalities. This includes small molecules, peptides, oligonucleotides and conjugates. We are currently further expanding our portfolio in the area of Proteolysis Targeting Chimeras (PROTACs). To advance the RIA project pipeline, a newly formed PROTAC team operates in a cross-disciplinary therapeutic area environment in close collaboration with biologists, DMPK and safety experts as well as pharmaceutical scientists.
You will join highly integrated project teams focused on the discovery of PROTAC based drugs. The position includes the identification and optimization of PROTACs up to clinical candidate stage. As a RIA authority in the field of PROTACs you contribute to specific RIA projects - as chemistry lead in a drug discovery project, including management of external resources and collaborations.
We are looking for a person with a strong scientific background in Medicinal Chemistry and previous experience in working on PROTACs. You have excellent verbal and written communication skills and the ability to engage and collaborate across boundaries. We believe that you are person with a problem-solving attitude and delivery focus, and a strong interest to continuously develop new skills in Medicinal Chemistry. Embedded in a strongly science driven environment, this position certainly includes opportunities to share scientific findings at conferences and publish novel science.
Main Duties and Responsibilities
* Design, synthesis and optimization of novel PROTACs up to clinical candidates
* Representation of Medicinal Chemistry as chemistry lead in respiratory project teams
* High level Medicinal Chemistry expertise to efficiently deliver within agreed timelines
* Proactively influence uptake of PROTACs as modalities into RIA portfolio where suited
* Efficient collaboration with biologists, DMPK and safety experts and pharmaceutical scientists
* Collaboration with academic partners and CROs
* Support extension of AstraZeneca 's scientific expertise with respect to the application of PROTACs for respiratory disease (inhalation, lung distribution and delivery aspects for PROTACs)
* Drive RIA 's scientific reputation by contributing conference presentations and publications together with internal and external partners
Essential Requirements
* PhD in Organic Chemistry or Medicinal Chemistry; post-doctoral experience is a plus
* Professional experience in Medicinal Chemistry and PROTACs, either in the Pharmaceutical Industry or in academia
* In-depth scientific knowledge of recent developments in PROTAC Medicinal Chemistry and modern synthetic methods
* A proven track record of delivery from own experimental work
* Excellent communication, influencing and collaboration skills
* Knowledge of the pharmaceutical drug discovery and development process
Are you ready to make a difference? Send in your application, and we'll make it happen together.
For more information about the position please contact:
Lena Ripa, RIA Medicinal Chemistry, at
Welcome with your application no later than June 15th, 2019!
Our Location
Our Gothenburg site is one of AstraZeneca's three strategic science centers. We thrive in a multinational environment working cross-functionally across the globe with AstraZeneca colleagues as well as academic and industry partners. Our way of life is to foster a working environment that nurtures, collaboration, openness and innovation. Therefore, we have created space for meetings, socializing and relaxation, where spontaneous meetings can give birth to new innovations. The unexpected ideas or thoughts that can come from a chat over something as simple as a cup of coffee or a stroll on our "walk and talk" meeting trail.
Our Gothenburg site:
https://www.astrazeneca.com/our-science/gothenburg.htmlLife in Gothenburg:
https://www.movetogothenburg.com/Culture and atmosphere of the Gothenburg site:
https://www.linkedin.com/feed/update/urn:li:activity:6496327311678410752/AstraZeneca is a global, innovation-driven biopharmaceutical company that focuses on the discovery, development and commercialization of prescription medicines for some of the world's most serious diseases. In addition to being one of the world's leading pharmaceutical companies, AstraZeneca is proud to provide a unique workplace culture that inspires innovation and cross-boundary collaboration.
Varaktighet, arbetstid
Heltid Permanent
Publiceringsdatum2019-05-17ErsättningNot Specified
Så ansöker duSista dag att ansöka är 2019-06-14
Ange följande referens när du ansöker: R-051124
Klicka på denna länk för att göra din ansökanKontaktAstraZeneca
karin.lyckemalm@astrazeneca.comFöretagAstraZeneca
AdressAstraZeneca
43183
43183 1480
KontorsadressPepparredsleden 1
Jobbnummer 4796099
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