Associate Director Integrated Bioanalysis - Proteomics
AstraZeneca AB / Biomedicinjobb / Göteborg
2023-11-17
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hela Sverige We are now looking for an Associate Director Integrated Bioanalysis - Proteomics to be part of the Integrated Bioanalysis (iBA) Global Team. The iBA group within Clinical Pharmacology and Safety Sciences (CPSS) provides broad discovery, preclinical, and clinical support including life cycle management across all therapeutic areas enabling pipeline delivery, decision making, innovation and advancement to improve the lives of patients through life-changing medicines. You will be located at our vibrant research hub in Gothenburg, Sweden where you will work alongside a team of experienced bioanalytical scientists supporting projects across our portfolio. You will also be working closely with discovery scientists across CPSS and partner line to maximise internal knowledge exchange and collaboration. This is an exciting opportunity with an immediate and lasting impact on our diverse pipeline.
What you'll do
In this role you will be responsible for advancing the utilisation and application of arrange of -omic technics with a specific focus on using mass spectrometry applications such as proteomics, metabolomics and lipidomic applications in discovery and early development. You will be expected to contribute to the development of advanced bioanalytical techniques across all aspect of AZ portfolio within Oncology and Biopharma.
You will be responsible for assay development, optimization, qualification, execution, and transfer of high complexity assays using state-of-art instrumentation to support pre-clinical and clinical studies. You will also contribute to tech-transfer to established CRO partners and may be called upon to review data to ensure assays are fit for purpose including troubleshooting and data analysis. You will furthermore be expected to provide scientific leadership to junior staff and to develop strong intra and inter-departmental collaborations.
You will need to use your experience and proven track record of experimental design to support delivery of robust bioanalytical data. You will also be called upon to interpret data and provide scientific insight. As a Subject Matter Expert, you will work closely with AstraZeneca laboratory groups within iBA and our vendor partners to ensure appropriate -omics methods are established and you will be responsible for enhancing the iBA reputation for scientific excellence by presenting at internal and external meetings, and publishing manuscripts.
You will be working with a dynamic team in a matrixed environment and will need to manage stakeholder expectations, give input to project strategy and delivery while being the main interface with experienced and highly skilled bioanalytical scientist colleagues or our partnered labs.
Essential for the role:
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PhD in analytical chemistry, biochemistry, genomics molecular biology or related discipline with at least 7 years of post-PhD experience.
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Proven experience as a Subject Matter Expert in an array of proteomics techniques including the development broad spectrum and targeted proteomics strategies.
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Experience in both hypothesis generation and targeted analyses approached to using proteomics to resolve to perform pathway analysis or biomarker strategies.
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Employ a metabolomic/proteomics discovery platform to enable discovery and validation of metabolomic/lipidomic/proteomics biomarkers.
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Experience using a broad array of proteomics platforms including but not limited to high resolution mass spectrometry (HRMS, ToF or Orbitrap), QqQ instruments and ligand binding based technology platforms.
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Hands-on experience with chromatographic separation, characterization, and quantification of various analytes by LCMS or protein array platforms.
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Proficiency with mass spectrometry and other protein array software, data analysis software (Spotfire, MATLAB, R, JMP, etc.) word processing, and graphical computer programs
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Experience of working with high-quality, timely documentation in electronic laboratory notebooks and technical reports which support regulatory filings.
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Ability to present data / strategy to scientists and management in internally.
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Background in pharmaceutical clinical trial research.
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A proven publication and presentation record.
To be successful in your role you need to have excellent organizational, documentation and technical writing skills. You have an ability to collaborate effectively to ensure productive interactions with all stakeholder groups. You show strong accountability and you have the ability to handle multiple projects and / or tasks concurrently in a fast-paced environment. You have exceptional verbal and written communication skills and an ability to develop, coach and mentor.
Desirable for the role:
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Experience with a broad array of multi-omic techniques including but not limited to RNA seq, cell- painting or genomics applications.
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Experience across a range of technology platforms including but not limited to LBA, Wester-blot, and PCR.
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Experienced in regulated bioanalysis for a range of drug modalities.
Why AstraZeneca in Gothenburg?
At AstraZeneca's Biopharmaceuticals R&D division, we are committed to making a difference. We have built our business around our passion for science. It's our combination of curiosity and courage that drives us, inspired by the possibility of doing things that have never been done before.
With more than 2,800 employees from over 70 countries, our vibrant Gothenburg site is a truly inspiring place to work. Here, the history and future of scientific breakthroughs come together. We believe that the diversity of our people is crucial to bringing new discoveries to life.
If this sounds like the job and place for you to make a change - apply today and come join our exciting journey! Welcome with your application no later than 15th of December, 2023.
Ersättning Not Specified
Så ansöker du Sista dag att ansöka är 2023-11-24
Klicka på denna länk för att göra din ansökan Arbetsgivarens referens Arbetsgivarens referens för detta jobb är "R-185094".
Omfattning Detta är ett heltidsjobb.
Arbetsgivare Astrazeneca AB (org.nr 556011-7482)
Arbetsplats AstraZeneca
Kontakt AstraZeneca
karin.tomin@astrazeneca.com Jobbnummer 8271385
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