Assistant professor in Epidemiological and Genetic Analysis of M
Karolinska Institutet, Institutionen för klinisk neurovetenskap / Sjukgymnastjobb / Stockholm
Observera att sista ansökningsdag har passerat.
Visa alla sjukgymnastjobb i Stockholm,
Solna,
Lidingö,
Sundbyberg,
Danderyd eller i
hela Sverige Visa alla jobb hos Karolinska Institutet, Institutionen för klinisk neurovetenskap i Stockholm,
Solna,
Huddinge eller i
hela Sverige The Department of Clinical Neuroscience (CNS) conducts research and education in the field of neuroscience from the molecular level to the society level. The clinical research and education is conducted in collaboration with other research groups from the Karolinska Institutet, with other universities as well as the Stockholm County Council.
Please visit our website for more information: ki.se/en/cns
Division
The Neuro division of CNS has a group of multiple sclerosis (MS) researchers with a research focus of understanding the pathogenesis, severity and progression of MS by integrating large-scale clinical information with molecular genetics, environmental/lifestyle data and registry data.
This work relies on intensive local, national and international collaborations.
Although clinical outcomes, including disease course, show increased concordance among relatives, little is known about the genetic and environmental contribution to severity and the mechanisms involved during MS progression. This is partly due to lack of well powered studies, limitations in measures of disease trajectories, omission of severity aspects other than motor function, and a lack of reliable biomarkers for disease progression. There are several ongoing projects that aims to fill these knowledge gaps one of them beingMultipleMS a CNS/KI coordinated EU/Horizon2020-funded consortium that aims to develop, validate and exploit methods for patient stratification in MS. MultipleMS will utilize uniquely large clinical cohorts with multiple data types, including genetic and lifestyle information, in combination with publically available multi-omics maps to identify biomarkers of the clinical course and the response to existing therapies, and to gain in-depth knowledge of distinct pathogenic pathways setting the stage for development of new interventions. Other projects are building on large biobanks collected within the EIMS, GEMS and IMSE studies that have collected genetic and lifestyle exposures on a large proportion of MS cases in Sweden. In this cohort we are currently exploring the use of alternative proxy measures of progression of MS based on linkages to national registries.
Duties
You will be responsible for developing measures of MS severity and progression, including disease trajectories and non-motor function-based severity scores, and for creating models that describe the disease course and other health parameters in MS. You will also collect, manage and quality assure genetic and phenotypic data, implement new measures and execute statistical and genetic analysis within the project.
Specific duties include:
- Manage genetic and phenotypic data.
- Integrating and quality assuring large-scale data sets and data from different national registers (e.g. Swedish MS Register, LISA, Patient Register, etc.).
- Survival analyses.
- Modeling disease and other health parameters.
- Develop measures for MS severity.
- Develop composite measures using longitudinal data that describe trajectory of MS disease course and progression.
- Develop statistical models that describe the disease course and other health parameters in MS.
- Carry out statistical analyses of clinical and environmental/lifestyle data.
- Carry out statistical genetic analyses for traits related to severity and progression of MS.
- Preparing and submitting grant applications and manuscripts for publication.
- Participate in teaching and supervision of students
•
Entry requirements
A person is eligible to be appointed Assistant professor if he or she has been awarded a Degree of Doctor or has achieved the corresponding scientific competence. The persons appointed should primarily be the ones who have been granted a Degree of Doctor or have reached the corresponding competence no more than seven years before the end of the application period.
Bases of assessment
We stress scientific expertise when assessing applicants.
- Ph.D. with substantial experience in the field of epidemiology of neuroinflammatory and/or neurodegenerative diseases
- Experience in the field of genetics of neuroinflammatory and/or neurodegenerative diseases
- Experience with practical aspects of project management
- Substantial knowledge in the field of Medical Statistics
- Excellent command of the English language (both spoken and written)
Key competencies
- Substantial documented experience of using software for epidemiological and genetic analysis (e.g. R, PLINK, Haploview or equivalent,) and handling large data sets in databases.
- Skills in writing scientific reports and scientific articles.
- Excellent social and communication skills, assertive personality
- Critical thinking and problem solving skills
- Planning and organizing skills
- Experience with collaborative projects and working with national and international collaborators.
- Experience with the Swedish MS Registry is not required but meritorious.
- Experience of supervising students is not required but meritorious
Application process
More information about the application process:
http://ki.se/om-ki/jobba-pa-kiKarolinska Institutet is one of the world's leading medical universities. Its vision is to significantly contribute to the improvement of human health. Karolinska Institutet accounts for the single largest share of all academic medical research conducted in Sweden and offers the country's broadest range of education in medicine and health sciences. The Nobel Assembly at Karolinska Institutet selects the Nobel laureates in Physiology or Medicine.
Pursuant to the regulations of the Swedish National Archives, applications are kept on file for two years after the appointment has gained legal force. The regulations do not apply to attachments that have been printed or otherwise published.
Karolinska Institutet strives to provide a workplace that has approximately the same number of women and men, is free of discrimination and offers equal opportunity to everyone.
For temp agencies and recruiters, and to salespersons: We politely, yet firmly, decline direct contact with temp agencies and recruiters, as well as those selling additional job announcements.
Varaktighet, arbetstid
100. Tillträde: According to agreement Visstidsanställning
Publiceringsdatum2018-01-09ErsättningMonthly salary
Så ansöker duSista dag att ansöka är 2018-01-29
Ange följande referens när du ansöker: 2-133/2018
Klicka på denna länk för att göra din ansökanKontaktCaisa Stilling, HR-administratör 08-524 832 82,
caisa.stilling@ki.seIngrid Kockum, Professor 08-5177 6258,
ingrid.kockum@ki.seFöretagKarolinska Institutet, Institutionen för klinisk neurovetenskap
AdressKarolinska Institutet, Institutionen för klinisk neurovetenskap
Administrationen, Tomtebodavägen 18a, plan 5
17177 Stockholm
KontorsadressAdministrationen, Tomtebodavägen 18a, plan 5
Jobbnummer 3891553
Observera att sista ansökningsdag har passerat.