Thesis Work: Dart-Ms For In-Line Tablet Batch Release
Randstad AB / Kemistjobb / Mölndal
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Direct Analysis in Real Time - Mass Spectrometry (DART-MS) for in-line tablet batch release
If you're inspired by the possibilities of science to make a difference and ready to discover what you can do - join us!
Thesis type: 30 or 60 credits
Project start: August/ September 2023
Student location: On Site, Gothenburg Sweden
Production of pharmaceutical tablets is moving from a batch-oriented to a continuous flow. Consequently the analysis needed for quality acceptance must be adapted for immediate results. Impurity analysis has still not been adapted for the new setup and for some products also content uniformity is lacking an analytical method.
The aim of this project is to develop and evaluate methodology for direct measurement on tablets by DART-MS or MSMS, and set up a flow for data processing by machine learning methods.
The project is a collaboration between Mass Spectrometry, Machine learning and Material Science experts and will give the student a broad knowledge in several key disciplines in late state drug development. Interest for analytical chemistry and multivariate techniques is needed.
DART-MS is a widely used, nondestructive technique for identifying substances in forensics, security and food industry, but it has so far been rarely used for quality attributes in drug production. The reason has not been lack in sensitivity but failing precision (ca 10%) as data interpretation has focused only on the measured component. The proposal in this project is to use the full spectrum from a Quadrupole-Time of Flight mass spectrometer (QTOF-MS) and use a trained machine learning algorithm to use the rest of the spectrum as internal standard. In this way we hope to be able to acquire both the impurity and content analysis in only one run that takes just one second, using no solvents or sample preparation.
At AstraZeneca, all of our employees make a difference to patients' lives every day. We operate in more than 100 countries around the world and are one of Sweden's most important export companies.
With more than 2,400 employees from 50 countries, the vibrant Gothenburg site helps to support the entire life-cycle of AstraZeneca medicines, from drug discovery and clinical trials, to global commercialisation and product maintenance. Gothenburg is one of AstraZeneca's three strategic, global R&D centres, alongside Cambridge and Gaithersburg, and plays a central role in our mission to deliver life-changing medicines to patients.
Randstad Life Sciences is collaborating with AstraZeneca in this recruitment process. Please send your application in English and we only accept applications through Randstad's website.
Deadline for application: 2023-05-28, selection and interviews will be ongoing. The position may be filled before the last day of application, therefore, apply as soon as possible.
For us, it is important that all competence and skills in the labor market are utilized. We welcome all applicants and strive for diversity.
Responsibilities
The aim of this project is to develop and evaluate methodology for direct measurement on tablets by DART-MS or MSMS, and set up a flow for data processing by machine learning methods.
The project is a collaboration between Mass Spectrometry, Machine learning and Material Science experts and will give the student a broad knowledge in several key disciplines in late state drug development. Interest for analytical chemistry and multivariate techniques is needed.
Qualifications
Ongoing education in chemistry, biotechnology, pharmacy or similar
Interest for analytical chemistry and multivariate techniques
Curiosity about the pharmaceutical industry and the late stage of drug development
About the company
If you're inspired by the possibilities of science to make a difference and ready to discover what you can do - join us!
At AstraZeneca we are guided in our work by a strong set of values, and we're resetting expectations of what a bio-pharmaceutical company can be. By truly following the science, we pioneer new methods, new thinking and bring unexpected teams together. From scientists to sales, lab techs to legal, we're on a mission to turn ideas into life-changing medicines that transform lives. We need great people who share our passion for science and have the drive and determination to meet the unmet needs of patients around the world. If you're swift to action, confident to lead, willing to collaborate, and curious about what science can do, then you're our kind of person.
AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law. AstraZeneca only employs individuals with the right to work in the country/ies where the role is advertised.
Ersättning Not specified
Så ansöker du Sista dag att ansöka är 2023-05-28
Klicka på denna länk för att göra din ansökan Arbetsgivarens referens Arbetsgivarens referens för detta jobb är "201436218".
Omfattning Detta är ett heltidsjobb.
Arbetsgivare Randstad AB (org.nr 556242-1718)
Arbetsplats Randstad
Kontakt Malin Fridholm
malin.fridholm@randstad.se Jobbnummer 7771531
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