Senior Research Scientist - Transgenic/PGE
AstraZeneca Göteborg / Apotekarjobb / Mölndal
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hela Sverige You will join the Discovery Sciences organization, working within a first-class scientific environment to support drug discovery. Transgenic and precise genome editing department of Discovery Sciences, is responsible for the generation of novel in vivo and in vitro reagents to support projects in all phases of the drug discovery pipeline. We are seeking 3 Senior Research Scientist to join our team in Gothenburg Sweden, where we focus on delivering in vivo and in vitro disease models for all AstraZeneca diseases areas including Oncology, Cardiovascular and Metabolic diseases and Respiratory and Autoimmunity.
The role
Applying strong expertise in the competency of precise genome editing and mouse model generation, working primarily with mouse models and cellular engineering with opportunities to use primary and iPS cells. The focus is on mouse line generation using traditional and precise genome editing approaches for use in target identification and target validation. To devise, champion and develop scientific areas aligned with project needs. To be an authority in the arena of in vivo science and precise genome editing, to lead this from a lab-based perspective and make significant contributions to the practical delivery of project goals. To coach and support more junior scientists by advising and challenging them and by providing expert advice to aid interpretation of complex data. To provide disciplinary scientific leadership and represent the department at internal interdisciplinary meetings in addition to external meetings and to publish novel science in high impact journals. To propose experimental strategies, troubleshoot problems and make significant contributions to the practical delivery of projects in compliance with AstraZeneca corporate responsibility policies and relevant safety standards.
It is essential to have good social and communication skills, be collaborative and a strong team player. Candidates should be able to work independently, take own initiatives and have a positive, goal oriented and problem solving attitude. Good organisational skills are required and you should be comfortable in presenting your results. Excellent English is required, both spoken and in writing.
Tasks:
• To develop in vitro reagents for target based approaches, target identification, target validation
• To design genome editing-based strategies and tools required to generate in vivo (mouse) and in vitro reagents to create disease models
• To perform genetic screenings using genome editing tools
• To perform confirmation of genetic manipulation and functional validation of engineered animals
• To perform target identification and target validation studies in early projects
Minimum experience
You should have a Ph. D. degree or corresponding experience in a relevant scientific discipline with experience in drug discovery or, alternatively, a first degree and significant relevant experience in drug discovery.
Desirable skills:
• Molecular biology and manipulation of cell lines, mouse embryonic stem cells, primary and iPSC cells
• Knowledge, generation and use of viruses (lentivirus, AAV, Adenovirus) for in vitro and in vivo model engineering
• Functional characterization of gene modified mouse lines
• In silico analysis of genetic perturbation after genome editing
Welcome with your application no later than October 10th, 2017
AstraZeneca is an exciting global, innovation-driven biopharmaceutical company. We're inspired by what science can do. Driven by the desire to meet unmet patient needs in our core therapeutic areas. Bold in our thinking. Proactive in pursuing discoveries beyond imagination. At sites across the world, we bring teams together in a spirit of collaboration to turn great ideas into life-changing medicines - strengthening our product portfolio and harnessing the potential of a pipeline across all stages of the drug development process.
You'll be part of a team that's rolling back the frontiers of science to turn yesterday's impossible into the normal of tomorrow. So, if you share our focus and passion, join us and make a difference to patients - and in return, we'll help you develop way beyond what you thought possible.
Publiceringsdatum2017-09-25Så ansöker duSista dag att ansöka är 2017-10-10
Ange följande referens när du ansöker: Senior Research Scientist
FöretagAstraZeneca Göteborg
AdressAstraZeneca Göteborg
Pepparedsleden 1
43183 MÖLNDAL
KontorsadressPepparedsleden 1
Jobbnummer 3717334
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