Senior Formulation Scientist - Advanced Drug Delivery
AstraZeneca AB / Kemistjobb / Göteborg
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hela Sverige At AstraZeneca, we turn ideas into life changing medicines and strive to continuously meet the unmet needs of patients worldwide. Working here means being entrepreneurial, thinking big, and working together to make the impossible a reality. If you are swift to action, confident to lead, willing to collaborate, and curious about what science can do, then you're our kind of person!
Pharmaceutical Sciences at AstraZeneca delivers the therapies of the future through scientific leadership in drug delivery, design of synthetic routes, and manufacturing of Active Pharmaceutical Ingredients (API) and drug products. Our portfolio of projects spans small molecules, peptides, oligonucleotides to RNA-based therapeutics across AstraZeneca's therapy areas. Advanced Drug Delivery (ADD) resides within Pharmaceutical Sciences with a mission to transform diverse modalities into investigational medicines.
We are now looking for a skilled and experienced Formulation Scientist to join us as Senior Scientist, in the New Modality Clinical Formulation team. The role sits within the ADD group at our vibrant R&D site in Gothenburg, Sweden.
What You'll do
This is an exciting role where you will act as a key member of various project teams and provide your technical and scientific expertise into formulation design and development strategies within the new modality and advanced drug delivery portfolio of antisense oligonucleotides (ASOs), small interference RNA (siRNA), peptides, and mRNA based therapeutics, with emphasis on parental formulation development. You will be responsible for defining lead enabling formulations to ensure desired clinical performance from discovery to Phase II, including a strong contribution to CMC (Chemistry, Manufacturing, Control) aspects and deliveries. In addition, you will lead GxP/non-GxP drug product manufacturing and outsourcing activities and strategies. As such, we are looking for a candidate who has a strong understanding of formulation, analytics, biopharmaceutics and drug delivery across various modalities and dosage forms.
The role will be expected to work cross-functionally supporting drug projects from early to late clinical phase and be involved in science & technology initiatives.
We are looking for you, who together with your team will make a difference for patients' lives every day. This through your ability to independently lead and achieve set goals within budget, time and to the right quality.
Essential for the role
* MSc degree with industrial experience within the field of Pharmaceutical/Biotechnology Science or PhD degree in relevant field (such as Chemistry, Pharmaceutics, Chemical Engineering or Biotechnology)
* Hands-on experience of formulation development with biomolecules (e.g. ASOs, siRNA, proteins and peptides)
* Good understanding of formulation science, drug delivery and biopharmaceutics to enable mechanistic understanding of in vivo drug product performance
* Knowledge and hands-on experience of analytical techniques to support formulation development (e.g. HPLC, DLS, spectroscopy)
* Ability and desire/willingness to effectively communicate, network and build collaborative relationships with partners across subject areas and cultures, internally and externally and independently lead and influence projects
Desired for the role
* Experience on clinical formulation development and design from the pharmaceutical industry, including knowledge of CMC deliveries and regulatory frameworks
* Knowledge of GxP manufacturing activities and strategies, including scale-up development, outsourcing, tech transfer, reviewing and approving documentation such as Manufacturing Methods and Master Batch Records
* Good understanding of the overall drug discovery and development process and an appreciation of how the Pharmaceutical Science field contributes to R&D
Why AstraZeneca?
At AstraZeneca we're dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. There's no better place to make a difference to medicine, patients and society. An inclusive culture that champions diversity and collaboration, and always committed to lifelong learning, growth and development. We're on an exciting journey to pioneer the future of healthcare.
So, what's next? We welcome your application no later than 27th November, 2023.
Ersättning Not Specified
Så ansöker du Sista dag att ansöka är 2023-11-23
Klicka på denna länk för att göra din ansökan Arbetsgivarens referens Arbetsgivarens referens för detta jobb är "R-184656".
Omfattning Detta är ett heltidsjobb.
Arbetsgivare Astrazeneca AB (org.nr 556011-7482)
Arbetsplats AstraZeneca
Kontakt AstraZeneca
galia.nystrom@astrazeneca.com Jobbnummer 8258620
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