Principal Scientist, Oligonucleotide Chemistry
AstraZeneca / Logistikjobb / Göteborg
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hela Sverige AstraZeneca R&D, IMED, Gothenburg, Sweden seek to recruit a Principal Scientist, New Modalities Chemistry in the area of Respiratory, Inflammation & Autoimmunity (RIA).
Mission
AstraZeneca is committed to the development of the next generation innovative respiratory medicines. The New Modalities Chemistry team in RIA leads the efforts focused on expanding the use of novel peptide and oligonucleotide based modalities and molecular conjugates in the treatment of respiratory diseases. The New Modalities team achieves this in close collaboration with scientists in the Chemistry, Bioscience, DMPK and Pharmaceutical Science departments - all joined by the goal to discover the respiratory medicines of the future.
Job description
* Develops and leads science in the field of oligonucleotide chemistry at the RIA Medicinal Chemistry Department
* Provides the scientific expertise needed to impact on multiple projects in all phases of oligonucleotide based drug discovery across the RIA IMED.
* Influences the direction of the RIA oligonucleotide strategic investments
* Responsible for the design and synthesis of oligonucleotides, both internally and within collaborations with external partners, including internal laboratory work and organization of CRO work applying state of the art knowledge
* Coaches and supports scientists within RIA by advising and challenging them, but also by providing expert knowledge and interpretation of complex data.
* Will be a RIA authority in oligonucleotide chemistry and make significant contributions to the delivery of project goals
* Identifies and drives collaborations and publication opportunities. Continuously publishes and presents results from own scientific work
* The jobholder has strong written and verbal communication skills. In addition, an ability to engage and collaborate across boundaries with a problem solving attitude and delivery focus
Main Duties and Responsibilities
* Directly impacts on the RIA IMED oligonucleotide projects to ensure high scientific standards and quality of compound design to meet project objectives
* Works with Department Head and TL New Modalities at RIA Medicinal Chemistry Department to build the strategic vision for the future development of oligonucleotides and their application to respiratory disease areas
* Actively inputs across RIA IMED departments to build the RIA oligonucleotide platform
* Identifies investment needs and leads setup of laboratory capabilities
* Maintains/develops key crossfunctional interactions (e.g. Pharmaceutical Sciences, Safety)
* Secures authorship of project patent applications and leads discussions on filing strategy together with AZ patent attorneys
* Mentors colleagues by providing expert advice and support of data interpretation
* Drives RIA IMED scientific reputation by identifying and progressing publication opportunities in the field of oligonucleotides internally, across AZ and/or together with external partners.
* Identifies/engages with leading internal and external experts; prepares grant applications
Essential Requirements
* PhD in organic chemistry or biochemistry; postdoc is a plus.
* >5 years of professional experience in pharmaceutical industry or academia
* Significant experience in drug discovery focused on oligonucleotide chemistry
* Documented experience of scientific leadership within oligonucleotide drug discovery
* In-depth scientific knowledge in the area of oligonucleotides including design, synthesis and data analysis proven by track record of project deliveries, publications and external presentations
* Experienced in the use and application of modern synthetic, analytical, biophysical and computational techniques used to progress oligonucleotide based projects
* Familiar with recent developments in areas relevant to oligonucleotide based drug discovery, e.g. pharmacokinetics, pharmacology, safety, formulation, and screening approaches
* Excellent communication and influencing skills
* Solid knowledge of pharmaceutical drug discovery process
Behaviours, Values, Leadership
* Fulfills leadership and behavioural criteria suitable for project leadership
* Applies a broad scientific perspective and actively engages with others
* Capable of building external networks, publishing and communicating science in an engaging and inspiring way
* Seeks external visibility and encourages smart risk taking
* Communicates and enables excellent collaboration with internal and external partners
If you are interested, apply now!
For more information about the position please contact: Dr. Frank Narjes, Medicinal Chemistry, IMED RIA at +46 31 7064664
Welcome with your application no later than February 18th, 2018.
AstraZeneca is a global, innovation-driven biopharmaceutical company that focuses on the discovery, development and commercialization of prescription medicines for some of the world's most serious diseases. In addition to being one of the world's leading pharmaceutical companies, AstraZeneca is proud to provide a unique workplace culture that inspires innovation and cross-boundary collaboration. The Respiratory, Inflammation & Autoimmunity (RIA) unit is one of AstraZeneca 's core therapy areas focused on the discovery and development of novel treatments for respiratory diseases.
Varaktighet, arbetstid
Heltid Permanent
Publiceringsdatum2018-01-29ErsättningNot Specified
Så ansöker duSista dag att ansöka är 2018-02-19
Ange följande referens när du ansöker: R-021572
Klicka på denna länk för att göra din ansökanKontaktAstraZeneca
asa.lothigius@astrazeneca.comFöretagAstraZeneca
AdressAstraZeneca
43183
43183 1480
KontorsadressPepparedleden 1
Jobbnummer 3931349
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