Postdoktor i diabetesforskning
Lunds Universitet / Apotekarjobb / Lund
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Placering: Institutionen för kliniska vetenskaper i Malmö, Malmö
Tillträde: 2013-03
Publiceringsdatum2012-12-20Dina arbetsuppgifterSubject: Type 2 Diabetes
Work environment:
The lab (headed by Nils Wierup)
http://www.ludc.med.lu.se/research-units/neuroendocrine-cell-biology/ is part of the Lund University Diabetes Centre, one of the strongest constellations for diabetes research in the world.
http://www.ludc.med.lu.se/The lab is situated at Clinical Research Centre at the Scania University Hospital in Malmö in southern Sweden. The post doc will work closely in a team with two PhD-students and one technician. In addition the post doc will team up with a network of collaborators within LUDC with expertise in cell signaling, genetics, molecular genetics, patch clamp and metabolomics.
Project title: Antidiabetic actions of CART
Background:
We have shown that Cocaine and Amphetamine-Regulated Transcript (CART) is an important islet hormone essential for maintaining normal islet function since CART KO mice exhibit diminished insulin secretion and glucose intolerance. CART is upregulated in islets of T2D patients and in rodent models of T2D and CART stimulates glucose-stimulated insulin secretion (GSIS) and insulin secretion stimulated with the incretin hormone GLP-1. Therefore we conclude that absence of CART results in islet dysfunction, and that CART, on the other hand, is upregulated in beta cells when there is a need for increased insulin production. The receptor for CART is still not identified. Using 2-D gel technology and MS-MS we have identified 3 putative binding partners to CART in INS-1 (832/13) cells. The CART receptor is a potential drug target for obesity- and T2D therapy and identification of the receptor would be an important step towards CART-based therapies.
Aims of the project:
1) Evaluate putative CART receptor candidates. 2) Investigate if CART reduces glucagon secretion in human islets and in vivo in mice. 3) Dissect the mechanism behind the protective effects of CART against glucotoxicity. 4) Examine how beta cell overexpression of CART affects metabolism in vivo.
Methodology:
Studies will be performed in clonal beta cells and rodent tissue explants, in vivo proof of concept experiment in diabetic animal models, translational studies of the function of CART in human tissues in vitro. Tools at hand are CART-adenoviral vectors, CART siRNA, CART-transgenic mice and CART KO mice.
Behörighet
PhD degree, no earlier than three years before the date of advertisement (max 3 years). This period is extended correspondingsly by parental leave, clinical service, and certain commissions of trust.
A strong background in the diabetes field, proven knowledge in insulin and glucagon secretion mechanisms, skills in molecular biology, animal handling, confocal imaging and histology. Excellence in the English language (written and spoken) is a prerequisite. The applicant should have an exam in molecular biology, biomedicine, medicine or similar. The application should include: CV, publication list with top 5 publications indicated, personal letter, reference letter from at least one internationally recognized senior scientist, diplomas of university degree and high school grades. Evaluation process: The applications will be ranked by 3 external and internal reviewers, enabling selection of a top group of 5 candidates. At least two of these will be called for interview. Since teamwork is crucial for the success of the project special emphasis will be put on the outcome of the interview.
Arbetstider och omfattningVisstidsanställning 6 månader eller längre
Heltid
Tidsbegränsad anställning 2 år
ErsättningFast lön
Så ansöker duSista dag att ansöka är 2013-01-16
Ansökningsförfarande
Registrera din ansökan elektroniskt under "Ansök online". Om du inte kan söka elektroniskt skicka din ansökan till: Registrator, Lunds universitet, Box 117, 221 00 Lund. Diarienummer MPA 2012/1256 ska anges i samband med handlingar som skickas via post.
Klicka på denna länk för att göra din ansökanAnsökan kan tyvärr inte göras via e-post.
KontaktNils Wierup, Docent 040-391414
nils.wierup@med.lu.seFacklig kontaktSACO: Lars-Åke Lööv 046-2228464
saco@saco.lu.seOFR/S: Lena Thiman 046-2229363
st@st.lu.seFöretagLunds Universitet
AdressLunds Universitet
Box 117
22100 LUND
Övriga kontaktuppgifterTelefonnummer: 046-2220000
E-postadress:
lu@lu.se Jobbnummer 1422482
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