Postdoctoral fellow in immunoregulation in intestinal tumors
Göteborgs universitet / Övriga jobb / Göteborg
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Duration of employment: 2 years. Extent 100%
First day of employment: As agreed
Subject area
Immunoregulation in intestinal tumors.
Subject area description
The overarching goal of our research is to determine mechanisms of immunoregulation in autoimmune diseases and tumor immunity. In this project we study immunoregulation in a mouse model for human coloncancer (the APCmin/+ mouse) that spontaneously develops tumors in the intestine. We have recently shown that natural killer T lymphocytes (NKT cells) have an immunoregulatory function in intestinal tumors, promoting tumor growth. By enhancing regulatory T lymphocytes and inducing an immunosuppressive environment in the tumor, an efficient immune response against the tumor is prevented. Moreover, tumor NKT cells are functionally altered and have a different transcription factor setup compared to NKT cells in lymphoid tissues. The aim of the announced project is to determine how the tumor affects the NKT cell functional capacity, and to identify the underlying mechanisms by which NKT cells promote an immunosuppresive environment.
Job assignments
Mechanistic studies of the immunoregulatory function of NKT cells in the APCmin/+ model using different genetically modified mice, cell sorting and transfers, flow cytometry, immunofluoresence and a diversity of molecular biology and cellular immunological methods. Total mRNA analysis and bioinformatics analysis are also included. The project also encompasses typing and responsibility for breeding and crossing of strains of genetically modified mice.
Eligibility
An achieved doctoral degree is compulsory for a position as postdoctor at the University of Gothenburg. The doctoral thesis shall be in a relevant area according to the specific position stated here. Since a position as postdoctor aims to give new holders of the doctorate the opportunity mainly to strengthen and develop their scholarly proficiency, we aim for those who have a doctoral degree not older than 3 years counting from last date of application.
The qualifications for academic positions are given in Chapter 4, Section 3 - 4 of the Higher Education Ordinance.
Assessment
We are looking for a motivated and enthusiastic postdoc that is able to work independently. A strong background in basic immunological research, and extensive experience with mouse work, murine disease models, breeding and typing is a requirement. Extensive experience with flow cytometry sorting and analysis is also required. Knowledge and research experience on T lymphocytes, immunoregulation, tumor immunology, and a broad methodological competence, including molecular biology, is a merit.
Regulations for the evaluation of qualifications for academic positions are given in Chapter 4, Section 3 - 4 of the Higher Education Ordinance.
For further information:
Regarding the position please contact Susanna Cardell, professor, +46 31 786 6228,
susanna.cardell@microbio.gu.se Unions
Union representatives at the University of Gothenburg:
http://www.gu.se/english/about_the_university/job-opportunities/union-representativesHow to apply
In order to apply for a position at the University of Gothenburg, you have to register an account in our online recruitment system. It is the responsibility of the applicant to ensure that the application is complete in accordance with the instructions in the job advertisement, and that it is submitted before the deadline.
The application should contain:
• A cover letter giving a brief description of previous research experience, and a motivation to why you are applying
• A CV including a list of publications
• Proof of completed PhD
• Contact details of two references
Closing date: 2017-10-13
The University of Gothenburg promotes equal opportunities, equality and diversity.
Salary is determined on an individual basis.
Applications will be destroyed or returned (upon request) two years after the decision of employment has become final. Applications from the employed and from those who appeal the decision will not be returned.
In connection to this recruitment, we have already decided which recruitment channels we should use. We therefore decline further contact with vendors, recruitment and staffing companies.
Varaktighet, arbetstid
Heltid/ Ej specificerat
Publiceringsdatum2017-08-29ErsättningGöteborgs Universitet tillämpar individuell lönesättning
Så ansöker duSista dag att ansöka är 2017-10-13
Klicka på denna länk för att göra din ansökanFöretagGöteborgs universitet
AdressGöteborgs universitet
Medicinaregatan 7B
40530 Göteborg
KontorsadressMedicinaregatan 7B
Jobbnummer 3666974
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