Postdoc in Tumor Biology
MTC Karolinska Institutet / Kemistjobb / Solna
2011-03-04
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Area of responsibilities/description of the work
The successful candidate will work within a larger project aiming for the discovery and characterization of pathological mechanisms in childhood cancers (neuroblastoma and medulloblastoma). The candidate will primarily focus on methods related to cell biology and biochemistry.
One project includes finding the effect of pro-apoptotic recombinant proteins on mitochondrial permeability and release of proteins/peptides. Another project aims for mapping the intra cellular effects of an anti-cancer agent. A third project means global quantitative proteomics of clinically distinct tumours and correlation of protein levels with clinical parameters and genetic subgroups. Sample preparations include subcellular fractionation by ultra-centrifugation and further protein fractionation. Proteins and peptides are identified by mass spectrometry using iTRAQ and high resolution nano-LC-MS. Emphasis is then put on post MS analysis, i.e. the cell biology required for characterization of the function and relevance of candidate proteins. Such validation includes siRNA, mammalian expression constructs, immunoprecipitation, western blot and immunohistochemistry.
The time period for the employment is two years.
Qualifications
To qualify, the applicant must hold a doctor's degree or a foreign qualification deemed equivalent to a doctorate. Applications are welcome from talented postdocs, with previous experience and publications in cell biology and biochemistry
Please send your application, marked with reference number 1503/2011, to reach us by no later than March 15 2011 to
Helene.Stambeck@ki.se . The following documents must be submitted with your application:
1. A full CV, including date of public defense, title of thesis, previous academic appointments, academic title, current position, academic distinctions and committee work
2. A full publication list
3. A brief outline of your current work (max. one page)
4. Contact information for references
5. Certificates testifying to sickness, service in the total defense, positions of trust in trade union organizations and student organizations, parental leave or similar circumstances
See Karolinska Institutet s homepage at
http://ki.se/qualificationsportfolio for information about the qualification portfolio.Please note that one copy of all documents will be kept by the college for a period of two years, in accordance with a directive from the National Archives. Published material submitted for review is excepted from this rule.
Karolinska Institutet aims to promote equal opportunities by encouraging a balanced gender distribution. We therefore particularly invite equal to apply for this position. We also value the qualities that ethnic and cultural diversity can contribute to the university.
The Department of Microbiology, Tumor and Cell Biology (MTC) is engaged in research and education in the fields of immunology, infection-, cell- and tumor biology. MTC, located at the Solna Campus of Karolinska Institutet, has more than 220 employees and 150 PhD students divided between 34 research groups.
Publiceringsdatum2011-03-04Arbetstider och omfattningVisstidsanställning 6 månader eller längre
Heltid
2 years.
ErsättningFast lön
Så ansöker duSista dag att ansöka är 2011-03-15
Ansökan kan skickas till e-postadress:
helene.stambeck@ki.seKontaktProfessor Marie Arsenian Henriksson
Associate Professor Per- Johan Jakobsson
Anne Eklöf telefon +46 8 524 866 78
Facklig kontaktAnders Örn SACO telefon +46 8 524 866 82,
Anders.Orn@ki.seTorbjörn Laggar ST telefon +46 8 524 862 12,
torbjorn.Laggar@ki.seGunnar Stenberg SEKO telefon +46 8 524 880 75,
Gunnar.Stenberg@ki.seFöretagMTC Karolinska Institutet
AdressMTC Karolinska Institutet
Box 280
17177 STOCKHOLM
KontorsadressNobels väg 16
KontaktuppgifterTelefonnummer: 08-7286400
Faxnummer: 08-304276
Jobbnummer 866888
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