Post-doc/Researcher
Malmö högskola / Administratörsjobb (offentlig verksamhet) / Malmö
2017-01-27
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➡️ Klicka här för den senare publicerade platsannonsen "Post-doc/Researcher" (publicerad 2018-04-05) ⬅️
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hela Sverige Visa alla jobb hos Malmö högskola i Malmö Improved diagnostics and treatment of aggressive cancer is one of the most challenging tasks in international research today. Circulating tumour cells (CTC) can be found in patients with cancer metastases of epithelial origin, and prognostically, patients with higher number of CTCs detected in blood have a worse outcome. The emergence of advanced technologies to isolate circulating tumour cells from patient-derived blood now provides the opportunity to test and validate the understanding of the metastatic process.
We have based our research in this project on the fact that tumour cells produce increased levels of glycoconjugates containing sialic acid (SA), or Neu5Ac which is often associated with with poor prognosis. Indeed, there is an urgent need for diagnostic tools for analysing and determining SA glycosylation motifs in tumor cells, but reagents with discriminative power and sufficient affinities for specific and sensitive detection are generally missing.
We therefore develop fluorescent molecularly imprinted polymers (MIPs), or "plastic antibodies" with "specific" recognition sites for SA (SAMIPs), i.e. for the use as specific detection of tumour cells. The main objectives for the current project are i) To utilise fluorescent nanoprobes for specific recognition of circulating tumour cell biomarkers in vitro and in vivo ii) To target and detect circulating tumour cells with combined fluorescence-based nanoprobe imaging and holographic cell morphology. Fluorescence analysis of cells binding SAMIPs will be performed using fluorescence microscopy and flow cytometry. Magnetic SA-specific MIPs will allow specific capture of the tumour cells with the help of magnetic columns. The measurement of physical and optical tumour cell properties using the 3D digital holographic microscope will follow, enabling an enrichment of captured CTCs from blood samples by sorting out larger tumuor cells from smaller white blood cells.
The project will be carried out in close collaboration with Umeå University, Lund University and our industry partners, Phase Holographic Imaging, ImaGene-iT and Truly Translational.
Apart from carrying out research within these areas the applicant is expected to take responsibility for the maintenance of the instruments involved and to be active by supervising postgraduate students and fellow scientists in the techniques, as well as participate in teaching at post-graduate and graduate level. Teaching at undergraduate level may also to some extent be required. In addition, the applicant should (when applicable) be responsible for contacts on operational level with involved industry partners and is also expected to take part in applications for external funding to support research activities.
Candidates must be cell biologists by training and have a doctoral degree (not more than three years before the last date for this application) together with a good track record in the field of molecular biology, cell biology or biomedical laboratory science. Experience in handling of cell cultures and assessment of clinical samples, cell sorting with MACS columns, live cell imaging and in glycan biology are necessary. Special considerations will be given to scientific expertise in and previous hands-on experience in more than one of the following methods: microscopic techniques (e.g. fluorescence microscopy, confocal microscopy, digital holographic microscopy), cell culture, magnetic cell separation, immunohistochemistry, flow cytometry. Experience in synthesis of nanoparticles and their evaluation will be considered an additional merit. Documented excellent level of English (understanding, speaking and writing) is essential. The candidate should also have good social skills and the ability to work in a team and collaborate with people in complementary disciplines. Previous experience from working in research projects that involved both industry and academia is highly valued.
The position is placed at the Faculty of Health and Society, Department of Biomedical Science. The education and research activities comprised by the faculty aim at contributing to the knowledge base in order to preserve, support and promote people's physical, psychological, and social health. Within the faculty research is conducted in areas ranging from science, technology and medicine to social science. At the interfaces between these, new and unique research areas are being generated. Furthermore, the research at the faculty is linked to the research programme Biofilms - Research Center for Biointerfaces at three of our faculties, which combines research with medical, dental, food and environmental applications, in close collaboration with regional industry.
Varaktighet, arbetstid
Temporary position, limited to 1 year, starting March 15th, 2017 but with the possibility of 1 year extension.
Publiceringsdatum2017-01-27Så ansöker duSista dag att ansöka är 2017-02-12
Ange följande referens när du ansöker: REK 2.2.1-2017/15
FöretagMalmö högskola
AdressMalmö högskola
Jan Waldenströms Gata 25
20506 Malmö
KontorsadressJan Waldenströms Gata 25
Jobbnummer 3287133
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