PhD student position in medical science - Regulation of the cort
Göteborgs universitet / Administratörsjobb (offentlig verksamhet) / Göteborg
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hela Sverige Publiceringsdatum2015-10-28Beskrivning av verksamhetenThe University of Gothenburg tackles society's challenges with diverse knowledge. 37 000 students and 6 000 employees make the university a large and inspiring place to work and study. Strong research and attractive study programmes attract scientists and students from around the world. With new knowledge and new perspectives, the University contributes to a better future.
Dina arbetsuppgifterType of employment: Fixed-term employment, 4 years Extent: 100 % Location: Sahlgrenska Academy, Gothenburg First day of employment: As agreed Reference number: UR 2015/908 Project title: Regulation of the cortical bone by WNT16. Job assignments: Sweden and Norway have the highest incidence of bone fractures in the world. Currently available osteoporosis drugs are effective in reducing vertebral fracture risk (mainly dependent on trabecular bone mass) while they are less effective in reducing non-vertebral fracture risk (mainly dependent on cortical bone mass) and most osteoporotic fractures actually occur at non-vertebral bone sites. Several studies suggest that trabecular and cortical bone respond differently to signals involved in the regulation of skeletal bone metabolism. Therefore, new insights into the biology of these two bone compartments could be of great clinical and therapeutic importance. Our human genetic studies demonstrate that the WNT16 locus is unique in being associated with cortical but not trabecular bone mass and to have a major impact on non-vertebral fracture risk. Furthermore, our recent mechanistic study, published in Nature Medicine, indicate that WNT16 is a unique, powerful osteoblast-derived regulator of cortical bone mass, which inhibits osteoclastogenesis. We hypothesize that novel osteoporosis treatments that target WNT16 might be useful to reduce fracture risk at cortical/non-vertebral bone sites. The overall aim of this doctoral research proposal is therefore to characterize the mechanisms by which WNT16 regulates cortical bone homeostasis and thereby non-vertebral fracture risk. Both in vivo mice models and molecular studies will be used. These studies will increase the knowledge of the regulation of cortical bone homeostasis and might open novel avenues for specific prevention or treatment non-vertebral fractures, which is a significant unmet medical need. We would like the applicants to motivate why they interested in the project and why they are suitable applicants. The PhD position comprises 4 years full-time studies and leads to a doctoral degree. The position is funded via doctoral studentship.
Utbildning och erfarenhetTo be admitted to third-cycle studies you must fulfill both the general and the specific entry requirements. The general entry requirements is fulfilled if you have: 1. completed a degree at a second-cycle level, or 2. completed at least 240 credits worth of studies of which at least 60 credits must be at a second-cycle level, or 3. acquired equivalent knowledge in some other way in Sweden or abroad. The specific entry requirements is fulfilled if you have completed the English B/6 course or is considered to have acquired equivalent knowledge through previous studies.
Varaktighet, arbetstid
Visstidsanställning 6 månader eller längre
Heltid
TillträdeAs agreed
ErsättningFast månads- vecko- eller timlön
Så ansöker duSista dag att ansöka är 2015-11-23
Appointment procedure: Please apply online at the University of Gothenburg job application portal:
Klicka på denna länk för att göra din ansökanKontaktSofia Movérare Skrtic, Institute of Medicine, Project supervisor
sofia.skrtic@gu.seFöretagGöteborgs universitet
AdressGöteborgs universitet
Box 100
40530 GÖTEBORG
KontorsadressVasagatan 33
Övriga kontaktuppgifterTelefonnummer: 031-7860000
Jobbnummer 2501749
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