PhD Student
Göteborgs universitet / Sjuksköterskejobb / Göteborg
2008-08-15
Observera att sista ansökningsdag har passerat.
➡️ Klicka här för den senare publicerade platsannonsen "PhD Student" (publicerad 2008-08-20) ⬅️
Visa alla sjuksköterskejobb i Göteborg,
Mölndal,
Partille,
Kungälv,
Lerum eller i
hela Sverige Visa alla jobb hos Göteborgs universitet i Göteborg,
Partille,
Lysekil,
Uddevalla,
Vänersborg eller i
hela Sverige PhD Student
REF NR G 213 3262/08 the Institute for Neuroscience and Physiology at the Sahlgrenska Academy, University of Gothenburg.
Application deadline: 2008-09-15
The PONCH (Pregnancy Obesity Nutrition Child Health) study The critical role of maternal nutritional status and food habits for optimizing the pregnancy outcome and child health
Project description
Major health disorders in adult life, including metabolic syndrome, obesity and diabetes, have long been thought to arise from the interactions between influences of adult lifestyle and a genetically determined susceptibility. Recent research, however, suggests that experience in very early life, including in utero, may be an important determinant of later risk to be exposed to these diseases. Over-nutrition and obesity is a rapidly growing problem in our society with large health care implications. As many as 30-40 % of all women in fertile age can be classified as overweight or obese. Entering pregnancy overweight or obese is associated with several pregnancy complications and they are more likely to give birth to babies with increased birth weight. Around 20% are born over 4kg today in Sweden. Large babies have an increased risk of obesity and insulin resistance in childhood as well as in adult age. Our primary hypothesis is that the maternal metabolic conditions including obesity with intake of a western diet alter maternal cytokine levels and thereby exposing the fetus to inflammatory mediators, which may program the fetus for later development of metabolic syndrome. We propose to study mechanism linking the unfavourable maternal nutritional status and food intake to pregnancy outcome and metabolic disease at childhood or adulthood of the offspring.
The objectives of the proposed study are to clarify: 1) prenatal programming consequences of being exposed to a maternal environment with obesity and altered cytokine levels 2) prenatal programming consequences of an atherogenic maternal diet or a diet rich in polyunsaturated n-3 fatty acids 3) prenatal programming consequences of a maternal diet that has an global energy restriction.
We will enrol two groups of pregnant women (n=160 in each group) 1) obese (BMI>30) 2) healthy controls (BMI=18-25) at 8-12 weeks of gestation. Both groups are further randomised in two diet intervention groups. In 1st and 3rd trimester blood samples for analysis of hormones and cytokines and abdominal sc adipose tissue biopsies will be obtained from the mothers and insulin sensitivity followed by oral glucose tolerance test. Dietary interviews with the women to allow for detailed analysis with regard to habitually dietary intake before and during pregnancy as well as physically activity level. Weight gain during pregnancy will be followed in the women. Gender, height, weight and head circumference will be obtained from the children at birth. Breast milk will be collected from the mothers at 1, 3 and 6 month after partus for analysis of cytokines and hormones. These studies will provide data about fetal mechanisms underlying adult disease and for designing interventions for the primary prevention of obesity and type 2-diabetes.
The project is part of the multidisciplinary graduate school Miljö och Hälsa (Environment and Health) coordinated by Centre for Environment and Sustainability at University of Gothenburg and Chalmers University of Technology. Terms of employment: two years of utbildningsbidrag and two years of doktorandanställning is guaranteed as PhD student.
Desired background: knowledge on advanced level in nutrition
Publiceringsdatum2008-08-15Arbetstider och omfattningVisstidsanställning 6 månader eller längre
Heltid
2 år utbilsningsbidarg 2 års doktorand anställning
ErsättningFast lön
Så ansöker duThe application must have reached the Sahlgrenska office no later than Monday
September 15, 2008. The application must be made on a special form; please see: Ansökan sker via företagets webbplats.
FöretagGöteborgs universitet
AdressGöteborgs universitet
Box 100
40530 GÖTEBORG
KontorsadressVasaparken
KontaktuppgifterTelefonnummer: 031-7860000
Faxnummer: 031-7861119
Jobbnummer 288126
Observera att sista ansökningsdag har passerat.