Diploma Work 30 hp - Planned for spring 2014
Proffice Life Science AB / Kemistjobb / Göteborg
2013-11-22
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hela Sverige Comparison of different analytical platforms for bioanalysis of oligonucleotides
Background:
There is an increase interest in oligonucleotide therapeutics. CVMD have now collaborations around therapeutic development of three different types of oligonucleotides. As a result there is a need of better in-house understanding around the pros and cons of different bioanalytical techniques for quantification of oligonucleotides in plasma or tissue. Suggested techniques in the literature are LC-MS/MS and hybridization assays based on ligand binding assay (LBA) platforms.
Goal:
• Comparison of different LBA-platforms based on sensitivity, selectivity, accuracy and precision. Comparison should be made on model siRNA, miRNA and mRNA
• For siRNA and miRNA comparison towards LC-MS/MS could be included
Work will include:
• Development/implementation of tissue homogenisation and RNA extraction
• Development and evaluation of sensitivity, selectivity, accuracy and precision on microplate, Luminex and Gyros platforms for siRNA, miRNA and mRNA model compounds
• (Development and evaluation of LC-MS/MS method for siRNA and miRNA model compound)
Relevant education for this work is believed to be:
Master in analytical chemistry or biochemistry.
Business: AstraZeneca
City: Mölndal
Deadline for applications: 2013-12-06
More information: Mathias Liljeblad and Pia Davidsson 031-7761000.
Publiceringsdatum2013-11-22Så ansöker duSista dag att ansöka är 2013-12-06
Ange följande referens när du ansöker: 200518498
Ansökan kan tyvärr inte göras via e-post.
Klicka på denna länk för att göra din ansökanKontaktFöretagProffice Life Science AB
AdressProffice Life Science AB
Jobbnummer 1710582
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