Associate Principal Scientist/SRS- Genomics Target Validation
AstraZeneca / Biologjobb / Göteborg
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hela Sverige At AstraZeneca we win through science, it's at the heart of our every success. That science is only possible when we all work together - we'll always make sure you're clear about how your role is connected to our wider mission to really show what science can do.
If you are motivated by the opportunity to challenge the boundaries of science - join us as Associate Principal Scientist - Target Validation at our R&D site in Gothenburg, Sweden. The content and extent of this position will be adapted to suit chosen candidate's background and experience, therefore we encourage Senior Scientists to apply for the role.
This is a unique opportunity that includes new collaborations with Human Longevity Inc, US the Wellcome Trust Sanger Institute, UK, and The Institute for Molecular Medicine, Finland. AstraZeneca will also establish an in-house Centre for Genomics Research which will develop a bespoke database comprising genome sequences from samples donated by patients in its clinical trials together with associated clinical and drug response data.
AstraZeneca believes that embedding genomics across its research and development platforms will:
* deliver novel insights into the biology of diseases
* enable the identification of new targets for medicines
* support selection of patients for clinical trials
* allow patients to be matched with treatments more likely to benefit them
In this role, you will devise, champion and develop methods, tools and strategies for target validation in animal and cellular models. You will deliver novel insights into the biology of diseases by testing findings of AstraZeneca Integrated Genomics Initiative Program. Furthermore, you will develop and execute experimental plans to validate disease associated variants. As an authority in a particular scientific area, you will lead from a lab-based perspective to make significant contributions to the practical delivery of project goals. By using genome perturbation tools, you will analyze data generated by genome wide screening.
We will rely on you to coach and support more junior scientists by advising and challenging them, but also by providing expert advice and interpretation of complex data. You will provide disciplinary scientific leadership and represents the department at interdisciplinary meetings internally as well as externally. Finally, you will make a significant contribution to the practical delivery of projects in accordance with SHE requirements and in compliance with all AstraZeneca Corporate responsibility policies.
Main Duties and Responsibilities
* Expertise with integrative 'omics analysis (transcriptomics, proteomics, metabolomics)
* Extensive hands on genome/base editing tools and functional genomics based on custom designed nucleases.
* Advanced understanding of genetic engineering in cell lines, primary cells or in vivo
* Expertise with Next Generation Sequencing analysis (including single cell sequencing) and expression analysis.
* Strong molecular biology skills including gDNA, PCR and RNA isolation and molecular cloning skills
* Solid understanding of statistics, quantitative data analysis, and data mining
* Familiarity with life sciences software and algorithms such as Spotfire, Blast, other sequence comparison methods in silico gene manipulation tools
* Innovative publications and excellent oral and written communication skills and organizational skills
This role is a technical specialist in the Target validation area - a hands-on lab-based role at the forefront of the Genome Editing technology with a focus on effective delivery, troubleshooting and putting ideas into action. The Associate Principal Scientist provides support, supervision and coaching to scientists, ensuring that methods run efficiently and correctly, developing and guiding the set-up of new methodologies.
Essential Requirements
Ideally should have a Ph.D. degree or corresponding experience in a relevant scientific discipline with several years of relevant experience in drug discovery and/or early development or in a leading academic institution.
Highly Desirable Requirements
* Have a thorough understanding of Innovative Medicines and how this science contributes to influence projects.
* Have a good understanding of the pharmaceutical industry in the global context and must be able to translate this into new business opportunities.
* Will have a recognized scientific expertise within the area of the role and will function as a scientific expert within project teams.
* Will serve as a role model and coach to junior scientists
If you are interested, apply now!
For more information about the position please contact Marcello Marseca
at +46 31 776 1364 or + 46 706 315840
Welcome with your application no later than April 13, 2018
AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law. AstraZeneca only employs individuals with the right to work in the country/ies where the role is advertised.
Varaktighet, arbetstid
Heltid Permanent
Publiceringsdatum2018-03-13ErsättningNot Specified
Så ansöker duSista dag att ansöka är 2018-04-10
Ange följande referens när du ansöker: R-024290
Klicka på denna länk för att göra din ansökanKontaktAstraZeneca
karin.lyckemalm@astrazeneca.comFöretagAstraZeneca
AdressAstraZeneca
43183
43183 1480
KontorsadressPepparredsleden 1
Jobbnummer 4018699
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